(S)-3-[3'-(2-Amino-ethyl)-6,4'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid methyl ester; compound with toluene-4-sulfonic acid

Base Information

• Chemical Name: (S)-3-[3'-(2-Amino-ethyl)-6,4'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid methyl ester; compound with toluene-4-sulfonic acid
• CAS No.: 139517-80-9
• Molecular Formula: C₇H₈O₃S*C₂₅H₃₄N₂O₆
• Molecular Weight: 630.759
• Mol file: 139517-80-9.mol

Synonyms:(S)-3-[3'-(2-Amino-ethyl)-6,4'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid methyl ester; compound with toluene-4-sulfonic acid

Chemical Property of (S)-3-[3'-(2-Amino-ethyl)-6,4'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid methyl ester; compound with toluene-4-sulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-[3'-(2-Amino-ethyl)-6,4'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid methyl ester; compound with toluene-4-sulfonic acid

There total 4 articles about (S)-3-[3'-(2-Amino-ethyl)-6,4'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid methyl ester; compound with toluene-4-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

toluene-4-sulfonic acid (104-15-4) + 3-<3-(2-azidoethyl)-4-methoxyphenyl>-N-tert-butoxycarbonyl-O-methyl-(S)-tyrosine methyl ester (139517-77-4) → (S)-3-[3'-(2-Amino-ethyl)-6,4'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid methyl ester; compound with toluene-4-sulfonic acid (139517-80-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; for 0.5h; under 760 Torr; Ambient temperature;

Reference yield:

3-(2-hydroxyethyl)-4-methoxybenzeneboronic acid (139517-73-0) → (S)-3-[3'-(2-Amino-ethyl)-6,4'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid methyl ester; compound with toluene-4-sulfonic acid (139517-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 41 percent / Pd3>4, Na₂CO₃ / 1,2-dimethoxy-ethane / 12 h / 100 °C

2: 77 percent / PPh₃, dimethyl azodicarboxyalte, hydrazoic acid / tetrahydrofuran; toluene / 1) 0 deg C, 30 min, 2) 15 min

3: 0.315 g / H₂ / 10percent Pd-C / methanol; tetrahydrofuran / 0.5 h / 760 Torr / Ambient temperature

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen azide; hydrogen; sodium carbonate; dimethyl azodicarboxylate; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; toluene;

Reference yield:

(S)-methyl-3-(3-bromo-4-methoxyphenyl)-2-((N-tert-butoxycarbonyl)(amino))propanoate (113327-44-9) → (S)-3-[3'-(2-Amino-ethyl)-6,4'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid methyl ester; compound with toluene-4-sulfonic acid (139517-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 41 percent / Pd3>4, Na₂CO₃ / 1,2-dimethoxy-ethane / 12 h / 100 °C

2: 77 percent / PPh₃, dimethyl azodicarboxyalte, hydrazoic acid / tetrahydrofuran; toluene / 1) 0 deg C, 30 min, 2) 15 min

3: 0.315 g / H₂ / 10percent Pd-C / methanol; tetrahydrofuran / 0.5 h / 760 Torr / Ambient temperature

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen azide; hydrogen; sodium carbonate; dimethyl azodicarboxylate; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; toluene;

upstream raw materials:

toluene-4-sulfonic acid

3-<3-(2-azidoethyl)-4-methoxyphenyl>-N-tert-butoxycarbonyl-O-methyl-(S)-tyrosine methyl ester

3-(2-hydroxyethyl)-4-methoxybenzeneboronic acid

(S)-methyl-3-(3-bromo-4-methoxyphenyl)-2-((N-tert-butoxycarbonyl)(amino))propanoate

Downstream raw materials:

3-<3-<2-α-benzyloxycarbonyl-N^δ-tert-butoxycarbonyl-(S)-ornithylamino>ethyl>-4-methoxyphenyl>-N-tert-butoxycarbonyl-O-methyl-(S)-tyrosinemethyl ester