(1-{5-[3-fluoro-4-(5-trifluoromethyl-1H-benzoimidazol-2-yl)phenyl]pyrazin-2-yl}piperidin-4-yl)acetic acid ethyl ester

Base Information

Chemical Name:(1-{5-[3-fluoro-4-(5-trifluoromethyl-1H-benzoimidazol-2-yl)phenyl]pyrazin-2-yl}piperidin-4-yl)acetic acid ethyl ester
CAS No.:1388144-56-6
Molecular Formula:C₂₇H₂₅F₄N₅O₂
Molecular Weight:527.521
Hs Code.:

Synonyms:(1-{5-[3-fluoro-4-(5-trifluoromethyl-1H-benzoimidazol-2-yl)phenyl]pyrazin-2-yl}piperidin-4-yl)acetic acid ethyl ester

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Chemical Property of (1-{5-[3-fluoro-4-(5-trifluoromethyl-1H-benzoimidazol-2-yl)phenyl]pyrazin-2-yl}piperidin-4-yl)acetic acid ethyl ester

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Technology Process of (1-{5-[3-fluoro-4-(5-trifluoromethyl-1H-benzoimidazol-2-yl)phenyl]pyrazin-2-yl}piperidin-4-yl)acetic acid ethyl ester

There total 3 articles about (1-{5-[3-fluoro-4-(5-trifluoromethyl-1H-benzoimidazol-2-yl)phenyl]pyrazin-2-yl}piperidin-4-yl)acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59184-90-6
ethyl (piperidin-4-yl)acetate

: 1388144-56-6
(1-{5-[3-fluoro-4-(5-trifluoromethyl-1H-benzoimidazol-2-yl)phenyl]pyrazin-2-yl}piperidin-4-yl)acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 - 55 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 1 h / 150 °C / Inert atmosphere; Sealed; Microwave irradiation

With sodium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1388144-55-5
ethyl [1-(5-chloropyrazin-2-yl)piperidin-4-yl]acetate

: 1370534-66-9
2-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole?

: 1388144-56-6
(1-{5-[3-fluoro-4-(5-trifluoromethyl-1H-benzoimidazol-2-yl)phenyl]pyrazin-2-yl}piperidin-4-yl)acetic acid ethyl ester

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; at 150 ℃; for 1h; Inert atmosphere; Sealed; Microwave irradiation;

Reference yield:

: 1370534-54-5
2-(6-bromopyridin-3-yl)-6-(trifluoromethyl)-1H-benzimidazole

: 1388144-56-6
(1-{5-[3-fluoro-4-(5-trifluoromethyl-1H-benzoimidazol-2-yl)phenyl]pyrazin-2-yl}piperidin-4-yl)acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 18 h / 100 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 1 h / 150 °C / Inert atmosphere; Sealed; Microwave irradiation

With potassium acetate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide;