2-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-4-methyl-pentanoic acid

Base Information

Chemical Name:2-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-4-methyl-pentanoic acid
CAS No.:182193-42-6
Molecular Formula:C₂₇H₄₀NO₆P
Molecular Weight:505.591
Hs Code.:

Synonyms:2-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-4-methyl-pentanoic acid

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Chemical Property of 2-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-4-methyl-pentanoic acid

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Technology Process of 2-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-4-methyl-pentanoic acid

There total 5 articles about 2-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 182193-40-4
2-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-4-methyl-pentanoic acid ethyl ester

: 182193-42-6
2-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-4-methyl-pentanoic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 12h;
DOI:10.1021/jo9603439

Reference yield:

: 768-90-1
1-Adamantyl bromide

: 182193-42-6
2-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Ag₂O / CHCl₃ / 1.33 h / Heating

2: 91 percent / 4 N NaOH / ethanol / 12 h

With sodium hydroxide; silver(l) oxide; In ethanol; chloroform;
DOI:10.1021/jo9603439

Reference yield:

: 87438-94-6
ethyl 2-isobutylacrylate

: 182193-42-6
2-[(Adamantan-1-yloxy)-(1-benzyloxycarbonylamino-ethyl)-phosphinoylmethyl]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1) hexamethyldisilazane / 1) 110 deg C, 1 h, 2) 90 deg C, 4 h

2: Ag₂O / CHCl₃ / 1.33 h / Heating

3: 91 percent / 4 N NaOH / ethanol / 12 h

With sodium hydroxide; 1,1,1,3,3,3-hexamethyl-disilazane; silver(l) oxide; In ethanol; chloroform;
DOI:10.1021/jo9603439