(5R)-5-benzyl-5-[4-(3,5-dimethoxyphenyl)-1H-imidazol-2-yl]-3-[(1R)-1-phenylethyl]-oxazolidine-2,4-dione

Base Information

Chemical Name:(5R)-5-benzyl-5-[4-(3,5-dimethoxyphenyl)-1H-imidazol-2-yl]-3-[(1R)-1-phenylethyl]-oxazolidine-2,4-dione
CAS No.:1430086-07-9
Molecular Formula:C₂₉H₂₇N₃O₅
Molecular Weight:497.55
Hs Code.:

Synonyms:(5R)-5-benzyl-5-[4-(3,5-dimethoxyphenyl)-1H-imidazol-2-yl]-3-[(1R)-1-phenylethyl]-oxazolidine-2,4-dione

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Chemical Property of (5R)-5-benzyl-5-[4-(3,5-dimethoxyphenyl)-1H-imidazol-2-yl]-3-[(1R)-1-phenylethyl]-oxazolidine-2,4-dione

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Technology Process of (5R)-5-benzyl-5-[4-(3,5-dimethoxyphenyl)-1H-imidazol-2-yl]-3-[(1R)-1-phenylethyl]-oxazolidine-2,4-dione

There total 10 articles about (5R)-5-benzyl-5-[4-(3,5-dimethoxyphenyl)-1H-imidazol-2-yl]-3-[(1R)-1-phenylethyl]-oxazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430086-26-2
(5R)-5-benzyl-N-[2-(3,5-dimethoxyphenyl)-2-oxoethyl]-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carboxamide

: 1430086-07-9
(5R)-5-benzyl-5-[4-(3,5-dimethoxyphenyl)-1H-imidazol-2-yl]-3-[(1R)-1-phenylethyl]-oxazolidine-2,4-dione

Guidance literature:: With ammonium acetate; acetic acid; at 100 ℃; for 40h; Inert atmosphere;

Reference yield:

: 1430086-26-2
(5R)-5-benzyl-N-[2-(3,5-dimethoxyphenyl)-2-oxoethyl]-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carboxamide

: 1430086-07-9
C₂₉H₂₇N₃O₅

Guidance literature:: With ammonium acetate; In acetic anhydride; at 100 ℃; for 40h;
DOI:10.1016/j.bmcl.2014.02.057

Reference yield:

: 56150-08-4
diethyl α-benzyl α-hydroxymalonate

: 1430086-07-9
(5R)-5-benzyl-5-[4-(3,5-dimethoxyphenyl)-1H-imidazol-2-yl]-3-[(1R)-1-phenylethyl]-oxazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / tetrahydrofuran / 0.08 h / 0 °C / Molecular sieve; Inert atmosphere

1.2: 4.5 h / 0 - 20 °C / Molecular sieve; Inert atmosphere

2.1: ethanol / 2 h / 70 °C / Inert atmosphere

3.1: Dess-Martin periodane / dichloromethane / 0.5 h / Inert atmosphere

4.1: ammonium acetate; acetic acid / 40 h / 100 °C / Inert atmosphere

With ammonium acetate; Dess-Martin periodane; acetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;