(1S,2S)-15N-(1-(benzylamino)-1-phenyl-3-methylbutan-2-yl)-4-nitrobenzenesulfonamide

Base Information

Chemical Name:(1S,2S)-15N-(1-(benzylamino)-1-phenyl-3-methylbutan-2-yl)-4-nitrobenzenesulfonamide
CAS No.:1421014-48-3
Molecular Formula:C₂₄H₂₇N₃O₄S
Molecular Weight:454.555
Hs Code.:

Synonyms:(1S,2S)-15N-(1-(benzylamino)-1-phenyl-3-methylbutan-2-yl)-4-nitrobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S)-15N-(1-(benzylamino)-1-phenyl-3-methylbutan-2-yl)-4-nitrobenzenesulfonamide

Chemical Property:

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Technology Process of (1S,2S)-15N-(1-(benzylamino)-1-phenyl-3-methylbutan-2-yl)-4-nitrobenzenesulfonamide

There total 8 articles about (1S,2S)-15N-(1-(benzylamino)-1-phenyl-3-methylbutan-2-yl)-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421014-40-5
(2R,3S)-2-phenyl-3-isopropyl-1-(4-nitrophenylsulfonyl)aziridine

: 42927-57-1
15N-benzylamine

: 1421014-48-3
(1S,2S)-15N-(1-(benzylamino)-1-phenyl-3-methylbutan-2-yl)-4-nitrobenzenesulfonamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2012.11.079

Reference yield:

: 111060-66-3
L-dibenzylvalinal

: 1421014-48-3
(1S,2S)-15N-(1-(benzylamino)-1-phenyl-3-methylbutan-2-yl)-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether; tetrahydrofuran / 1 h / 0 °C

2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 24 h / 20 °C

3: thionyl chloride / toluene / 15 h / 0 - 40 °C

4: sodium hydroxide / methanol / 27 h / 20 - 50 °C

5: triethylamine / dichloromethane / 0 - 20 °C

6: triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With thionyl chloride; 10 wt% Pd(OH)2 on carbon; hydrogen; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2012.11.079

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1421014-48-3
(1S,2S)-15N-(1-(benzylamino)-1-phenyl-3-methylbutan-2-yl)-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide; potassium carbonate / ethanol; water / 12 h / 20 °C / Reflux

2.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 0 - 20 °C

3.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 0.25 h / -70 °C

3.2: -70 - 20 °C

4.1: diethyl ether; tetrahydrofuran / 1 h / 0 °C

5.1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 24 h / 20 °C

6.1: thionyl chloride / toluene / 15 h / 0 - 40 °C

7.1: sodium hydroxide / methanol / 27 h / 20 - 50 °C

8.1: triethylamine / dichloromethane / 0 - 20 °C

9.1: triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; oxalyl dichloride; 10 wt% Pd(OH)2 on carbon; hydrogen; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1016/j.tetlet.2012.11.079