(4R,5S)-3-[(E)-(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-iodo-2,4-dimethyl-pent-4-enoyl]-4-methyl-5-phenyl-oxazolidin-2-one

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Chemical Name:(4R,5S)-3-[(E)-(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-iodo-2,4-dimethyl-pent-4-enoyl]-4-methyl-5-phenyl-oxazolidin-2-one
CAS No.:106484-91-7
Molecular Formula:C₂₃H₃₄INO₄Si
Molecular Weight:543.517
Hs Code.:
Mol file:106484-91-7.mol

Synonyms:(4R,5S)-3-[(E)-(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-iodo-2,4-dimethyl-pent-4-enoyl]-4-methyl-5-phenyl-oxazolidin-2-one

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Chemical Property of (4R,5S)-3-[(E)-(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-iodo-2,4-dimethyl-pent-4-enoyl]-4-methyl-5-phenyl-oxazolidin-2-one Edit

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Technology Process of (4R,5S)-3-[(E)-(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-iodo-2,4-dimethyl-pent-4-enoyl]-4-methyl-5-phenyl-oxazolidin-2-one

There total 4 articles about (4R,5S)-3-[(E)-(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-iodo-2,4-dimethyl-pent-4-enoyl]-4-methyl-5-phenyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 106484-90-6
(4R,5S)-3-((E)-(2R,3R)-3-Hydroxy-5-iodo-2,4-dimethyl-pent-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one

: 106484-91-7
(4R,5S)-3-[(E)-(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-iodo-2,4-dimethyl-pent-4-enoyl]-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1039/P19900000047

Reference yield:

: 77877-20-4
(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one

: 106484-91-7
(4R,5S)-3-[(E)-(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-iodo-2,4-dimethyl-pent-4-enoyl]-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 9-Borabicyclo<3.3.1>nonyl trifluoromethanesulphonate, i-Pr₂NEt / 1.) CH₂Cl₂, T < 2 deg C, 1 h, 2.) a) 1 h, -78 deg C, b) 1 h, 25 deg C

2: 98 percent / 2,6-Lutidine / CH₂Cl₂ / 2 h / 0 °C

With 2,6-dimethylpyridine; N-ethyl-N,N-diisopropylamine; 9-BBN triflate; In dichloromethane;
DOI:10.1039/P19900000047