N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-4-fluorophenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Base Information

Chemical Name:N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-4-fluorophenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide
CAS No.:1228465-57-3
Molecular Formula:C₂₅H₁₉ClF₄N₆O₂S
Molecular Weight:578.977
Hs Code.:

N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-4-fluorophenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Synonyms:N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-4-fluorophenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

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Chemical Property of N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-4-fluorophenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

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Technology Process of N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-4-fluorophenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

There total 13 articles about N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-4-fluorophenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1125632-85-0
N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropane carboxamide

: 327-78-6
4-chloro-3-(trifluoromethyl)phenyl isocyanate

: 1228465-57-3
N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-4-fluorophenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

: 332370-72-6
N-(tert-butoxycarbonyl)-4-fluoro-3-nitroaniline

: 1228465-57-3
N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-4-fluorophenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr

3.1: tetrahydrofuran / 18 h / 4 - 10 °C

4.1: trifluoroacetic acid / 2 h / 4 - 10 °C

5.1: N,N-dimethyl-formamide / 22 h / 140 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 14 h / 20 °C / 760.05 Torr

7.1: acetic acid / 0.17 h / 20 °C

7.2: 0.17 h / 20 °C

8.1: bromine; acetic acid / 20 h / 20 °C

9.1: pyridine / 1 h / 4 - 20 °C

10.1: ethanol; sodium tetrahydroborate; methanol / 0.5 h / 4 °C

10.2: 0.08 h / 20 °C

11.1: N,N-dimethyl-formamide / 6 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; ethanol; hydrogen; bromine; caesium carbonate; acetic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1228465-57-3
N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-4-fluorophenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 22 h / 140 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 14 h / 20 °C / 760.05 Torr

3.1: acetic acid / 0.17 h / 20 °C

3.2: 0.17 h / 20 °C

4.1: bromine; acetic acid / 20 h / 20 °C

5.1: pyridine / 1 h / 4 - 20 °C

6.1: ethanol; sodium tetrahydroborate; methanol / 0.5 h / 4 °C

6.2: 0.08 h / 20 °C

7.1: N,N-dimethyl-formamide / 6 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; ethanol; hydrogen; bromine; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;