N-(3-azidopropyl)-4-(3-methoxy-5-oxocyclohex-3-enecarboxamido)benzamide

Base Information

• Chemical Name: N-(3-azidopropyl)-4-(3-methoxy-5-oxocyclohex-3-enecarboxamido)benzamide
• CAS No.: 1310048-41-9
• Molecular Formula: C₁₈H₂₁N₅O₄
• Molecular Weight: 371.396
• Mol file: 1310048-41-9.mol

Synonyms:N-(3-azidopropyl)-4-(3-methoxy-5-oxocyclohex-3-enecarboxamido)benzamide

Chemical Property of N-(3-azidopropyl)-4-(3-methoxy-5-oxocyclohex-3-enecarboxamido)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(3-azidopropyl)-4-(3-methoxy-5-oxocyclohex-3-enecarboxamido)benzamide

There total 2 articles about N-(3-azidopropyl)-4-(3-methoxy-5-oxocyclohex-3-enecarboxamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

4-amino-N-(3-azidopropyl)benzamide (1310048-40-8) + 3-methoxy-5-oxo-cyclohex-3-ene-1-carboxylic acid (95298-68-3) → N-(3-azidopropyl)-4-(3-methoxy-5-oxocyclohex-3-enecarboxamido)benzamide (1310048-41-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1002/anie.201007871

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → N-(3-azidopropyl)-4-(3-methoxy-5-oxocyclohex-3-enecarboxamido)benzamide (1310048-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1002/anie.201007871

Reference yield: 99.0%

N-(3-azidopropyl)-4-(3-methoxy-5-oxocyclohex-3-enecarboxamido)benzamide (1310048-41-9) → C17H19N5O4 (1310048-34-0)

Guidance literature:

With ammonium cerium (IV) nitrate; water; In acetonitrile; at 95 ℃; for 3h; Inert atmosphere;

DOI:10.1002/anie.201007871

upstream raw materials:

4-amino-N-(3-azidopropyl)benzamide

3-methoxy-5-oxo-cyclohex-3-ene-1-carboxylic acid

4-amino-benzoic acid

Downstream raw materials:

C₁₇H₁₉N₅O₄