(2-iodophenyl)phosphonate de diethyle

Base Information

• Chemical Name: (2-iodophenyl)phosphonate de diethyle
• CAS No.: 71838-14-7
• Molecular Formula: C₁₀H₁₄IO₃P
• Molecular Weight: 340.098
• Mol file: 71838-14-7.mol

Synonyms:(2-iodophenyl)phosphonate de diethyle

Chemical Property of (2-iodophenyl)phosphonate de diethyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-iodophenyl)phosphonate de diethyle

There total 4 articles about (2-iodophenyl)phosphonate de diethyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) + triethyl phosphite (122-52-1) → (2-iodophenyl)phosphonate de diethyle (71838-14-7)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; iodoform; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 65 ℃; for 24h; Molecular sieve;

DOI:10.1021/acs.joc.1c00550

Reference yield:

2-iodophenylamine (615-43-0) → (2-iodophenyl)phosphonate de diethyle (71838-14-7)

Guidance literature:

Multi-step reaction with 3 steps

1: liquid ammonia / 0.58 h / -33 °C / Irradiation

2: H(+), NaNO₂

3: KI

With hydrogen cation; potassium iodide; sodium nitrite; In ammonia;

DOI:10.1016/S0040-4020(01)97188-1

Reference yield:

(2-aminophenyl)phosphonic acid diethyl ester (31238-50-3) → (2-iodophenyl)phosphonate de diethyle (71838-14-7)

Guidance literature:

With hydrogenchloride; potassium iodide; sodium nitrite; Yield given. Multistep reaction; 1.) H₂O, O-5 deg C, 15 min; 2.) H₂O, 5 h;

upstream raw materials:

(2-aminophenyl)phosphonic acid diethyl ester

2-iodophenylamine

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

triethyl phosphite

Downstream raw materials:

phenylene-1,2-diphosphonic acid tetraethyl ester

Refernces

• 1、 Chen, Qian,Han, Yukun,Hu, Yifan,Huang, Yuanting,Huo, Yanping,Li, Xianwei,Ou, Yingcong. "Direct synthesis of ortho-halogenated arylphosphonates via a three-component reaction involving arynes". . p. 7010 - 7018. Retrieved 2021/05/29.