N-(2-chloro-6-methylphenyl)-O-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl) trifluoroacetimidate

Base Information

Chemical Name:N-(2-chloro-6-methylphenyl)-O-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl) trifluoroacetimidate
CAS No.:1228757-60-5
Molecular Formula:C₄₃H₄₁ClF₃NO₆
Molecular Weight:760.25
Hs Code.:

Synonyms:N-(2-chloro-6-methylphenyl)-O-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl) trifluoroacetimidate

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Chemical Property of N-(2-chloro-6-methylphenyl)-O-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl) trifluoroacetimidate

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Technology Process of N-(2-chloro-6-methylphenyl)-O-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl) trifluoroacetimidate

There total 3 articles about N-(2-chloro-6-methylphenyl)-O-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl) trifluoroacetimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 4291-69-4,6386-24-9,6564-72-3,59531-24-7,69257-52-9,78184-89-1,78609-16-2,78609-17-3,78609-18-4,96553-53-6,104111-61-7,131347-08-5,4132-28-9
2,3,4,6-Tetra-O-benzyl-D-glucopyranose

: 1228757-56-9
N-(2-chloro-6-methylphenyl)trifluoroacetimidoyl chloride

: 1228757-60-5
N-(2-chloro-6-methylphenyl)-O-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl) trifluoroacetimidate

Guidance literature:: 2,3,4,6-Tetra-O-benzyl-D-glucopyranose; With 15-crown-5; sodium hydride; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

N-(2-chloro-6-methylphenyl)trifluoroacetimidoyl chloride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1080/07328301003597673

Reference yield:

: 87-63-8
2-chloro-6-methylaniline

: 1228757-60-5
N-(2-chloro-6-methylphenyl)-O-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl) trifluoroacetimidate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 3 h / 20 °C

2.1: tetrachloromethane; triphenylphosphine / dichloromethane / 4 h / 60 °C

3.1: 15-crown-5; sodium hydride / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

With tetrachloromethane; 15-crown-5; sodium hydride; triphenylphosphine; In dichloromethane;
DOI:10.1080/07328301003597673

Reference yield:

: 941476-75-1
N-(2-chloro-6-methylphenyl)trifluoroacetamide

: 1228757-60-5
N-(2-chloro-6-methylphenyl)-O-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl) trifluoroacetimidate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrachloromethane; triphenylphosphine / dichloromethane / 4 h / 60 °C

2.1: 15-crown-5; sodium hydride / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

With tetrachloromethane; 15-crown-5; sodium hydride; triphenylphosphine; In dichloromethane;
DOI:10.1080/07328301003597673