(4R)-3-(2-fluoro-4-nitrophenyl)-4-ethyl-2-(trifluoromethyl)-1,3-oxazolidine

Base Information

• Chemical Name: (4R)-3-(2-fluoro-4-nitrophenyl)-4-ethyl-2-(trifluoromethyl)-1,3-oxazolidine
• CAS No.: 941291-37-8
• Molecular Formula: C₁₂H₁₂F₄N₂O₃
• Molecular Weight: 308.232

Synonyms:(4R)-3-(2-fluoro-4-nitrophenyl)-4-ethyl-2-(trifluoromethyl)-1,3-oxazolidine

Chemical Property of (4R)-3-(2-fluoro-4-nitrophenyl)-4-ethyl-2-(trifluoromethyl)-1,3-oxazolidine

Chemical Property:

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Technology Process of (4R)-3-(2-fluoro-4-nitrophenyl)-4-ethyl-2-(trifluoromethyl)-1,3-oxazolidine

There total 2 articles about (4R)-3-(2-fluoro-4-nitrophenyl)-4-ethyl-2-(trifluoromethyl)-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2R)-(+)-2-(2-fluoro-4-nitrophenyl)amino-1-butanol (329229-75-6) + ethyl trifluoroacetaldehyde hemiacetal (433-27-2) → (4R)-3-(2-fluoro-4-nitrophenyl)-4-ethyl-2-(trifluoromethyl)-1,3-oxazolidine (941291-37-8)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; Heating;

DOI:10.1021/jm061329j

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → (4R)-3-(2-fluoro-4-nitrophenyl)-4-ethyl-2-(trifluoromethyl)-1,3-oxazolidine (941291-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / NaHCO₃ / dimethylformamide / 12 h / 90 °C

2: 85 percent / p-toluenesulfonic acid / benzene / Heating

With sodium hydrogencarbonate; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm061329j

Reference yield: 59.0%

(4R)-3-(2-fluoro-4-nitrophenyl)-4-ethyl-2-(trifluoromethyl)-1,3-oxazolidine (941291-37-8) → (2R)-2-[2-fluoro-4-nitro(2,2,2-trifluoroethyl)anilino]-1-butanol (329229-77-8)

Guidance literature:

With triethylsilane; boron trifluoride diethyl etherate; In chloroform; for 24h; Heating;

DOI:10.1021/jm061329j

upstream raw materials:

(2R)-(+)-2-(2-fluoro-4-nitrophenyl)amino-1-butanol

ethyl trifluoroacetaldehyde hemiacetal

3,4-difluoronitrobenzene

Downstream raw materials:

(2R)-2-[2-fluoro-4-nitro(2,2,2-trifluoroethyl)anilino]-1-butanol

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