ethyl 1-benzyl-3-methyl-9-oxo-4,9-dihydro-1H-benzindole-2-carboxylate

Base Information

• Chemical Name: ethyl 1-benzyl-3-methyl-9-oxo-4,9-dihydro-1H-benzindole-2-carboxylate
• CAS No.: 151646-84-3
• Molecular Formula: C₂₃H₂₁NO₃
• Molecular Weight: 359.425
• Mol file: 151646-84-3.mol

Synonyms:ethyl 1-benzyl-3-methyl-9-oxo-4,9-dihydro-1H-benzindole-2-carboxylate

Chemical Property of ethyl 1-benzyl-3-methyl-9-oxo-4,9-dihydro-1H-benzindole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-benzyl-3-methyl-9-oxo-4,9-dihydro-1H-benzindole-2-carboxylate

There total 1 articles about ethyl 1-benzyl-3-methyl-9-oxo-4,9-dihydro-1H-benzindole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-<<1-benzyl-2-(ethoxycarbonyl)-3-methyl-1H-pyrrol-4-yl>methyl>benzoic acid (151646-86-5) → ethyl 1-benzyl-3-methyl-9-oxo-4,9-dihydro-1H-benzindole-2-carboxylate (151646-84-3)

Guidance literature:

With trifluoroacetic acid; trifluoroacetic anhydride; for 1h; Ambient temperature;

DOI:10.1002/jhet.5570300137

Reference yield: 56.0%

ethyl 1-benzyl-3-methyl-9-oxo-4,9-dihydro-1H-benzindole-2-carboxylate (151646-84-3) + dimethyl sulfate (77-78-1) → ethyl 1-benzyl-9-methoxy-3-methyl-1H-benzindole-2-carboxylate (151646-85-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

DOI:10.1002/jhet.5570300137

Reference yield:

ethyl 1-benzyl-3-methyl-9-oxo-4,9-dihydro-1H-benzindole-2-carboxylate (151646-84-3) → 1-benzyl-9-methoxy-3-methyl-5,6,7,8-tetrahydro-1H-benzindole

Guidance literature:

Multi-step reaction with 4 steps

1: 56 percent / K₂CO₃ / dimethylformamide / 0.33 h / 0 °C

2: KOH / ethanol / 0.75 h / Heating

3: copper chromite / quinoline / 0.25 h / 200 °C

4: 73 percent / Raney Ni-W₄ / ethanol / 1.5 h / Heating

With potassium hydroxide; copper chromite; Raney Ni-W₄; potassium carbonate; In quinoline; ethanol; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570300137

upstream raw materials:

2-<<1-benzyl-2-(ethoxycarbonyl)-3-methyl-1H-pyrrol-4-yl>methyl>benzoic acid

Downstream raw materials:

ethyl 1-benzyl-9-methoxy-3-methyl-1H-benzindole-2-carboxylate

1-benzyl-9-methoxy-3-methyl-1H-benzindole-2-carboxylic acid

1-benzyl-9-methoxy-3-methyl-1H-benzindole