Noracymethadol

Base Information

• Chemical Name: Noracymethadol
• CAS No.: 1477-39-0
• Molecular Formula: C22H29 N O2
• Molecular Weight: 339.478
• European Community (EC) Number: 216-027-8
• UNII: KU5U13XY7J
• DSSTox Substance ID: DTXSID30860679
• Nikkaji Number: J7.499C
• Wikipedia: Noracymethadol
• Wikidata: Q13218264
• NCI Thesaurus Code: C170231
• ChEMBL ID: CHEMBL2111032
• Mol file: 1477-39-0.mol

Synonyms:1 alpha-acetylnormethadol;6-(methylamino)-4,4-diphenyl-3-heptanol acetate;l-alpha-noracetylmethadol;N-desmethyl-1-alpha-acetylmethadol;NLAAM;nor-LAAM;noracetylmethadol;paracymethadol;paracymethadol hydrochloride;paracymethadol hydrochloride, (R*,R*)-(+-)-isomer;paracymethadol hydrochloride, (S-(R*,R*))-isomer;paracymethadol, (R*,R*)-(+-)-isomer;paracymethadol, (R-(R*,R*))-isomer;paracymethadol, (S-(R*,R*))-(-)-isomer

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Noracymethadol

Chemical Property:

• Vapor Pressure: 1.82E-08mmHg at 25°C
• Refractive Index: 1.528
• Boiling Point: 455°C at 760 mmHg
• Flash Point: 229°C
• PSA: 38.33000
• Density: 1.024g/cm³
• LogP: 4.70330
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 339.219829168
• Heavy Atom Count: 25
• Complexity: 379

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C(CC(C)NC)(C1=CC=CC=C1)C2=CC=CC=C2)OC(=O)C
• Uses: Analgesic. Noracymethadol is a synthetic opioid. It exhibits similar effects to morphine (CAS# 57-27-2) with less side effects.

Technology Process of Noracymethadol

There total 1 articles about Noracymethadol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Noracetylmethadone (1477-39-0)

Guidance literature:

α-1-Acetylmethadol in Eg., Hg(II)-acetat, 100grad;

DOI:10.1021/jm00240a024

Reference yield: 44.5%

methyl (E)-4-chloro-4-oxo-2-butenoate (17081-97-9) + Noracetylmethadone (1477-39-0) → α-(+/-)-N-noracetylmethadol

Guidance literature:

With sodium carbonate; In water; acetone; for 4h; Ambient temperature;

Reference yield:

cyclopropanecarboxylic acid chloride (4023-34-1) + (-)-α-acetyl-N-normethadol (1477-39-0,43033-71-2,55123-61-0,60966-53-2) → (-)-α-N-(cyclopropylcarbonyl)-N-noracylmethadol (77886-82-9)

Guidance literature:

With potassium carbonate; In benzene; for 1h; Heating;

DOI:10.1021/jm00139a030

Downstream raw materials:

(-)-α-N-(cyclopropylcarbonyl)-N-noracylmethadol

(-)-α-N-allyl-N-noracetylmethadol