6-KETOESTRONE

Base Information

• Chemical Name: 6-KETOESTRONE
• CAS No.: 1476-34-2
• Molecular Formula: C₁₈H₂₀O₃
• Molecular Weight: 284.355
• Mol file: 1476-34-2.mol

Synonyms:6-Ketoestrone;6-Oxoestrone

Chemical Property of 6-KETOESTRONE

Chemical Property:

• PSA: 54.37000
• LogP: 3.45760

Purity/Quality:

98%min ^*data from raw suppliers

6-KetoEstrone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The oxidative metabolite of 17β-Estradiol (E887995) and Estrone (E889050) formed by 15 selectively expressed human cytochrome p450 isoforms.

Technology Process of 6-KETOESTRONE

There total 20 articles about 6-KETOESTRONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-ketoestradiol (571-92-6) → 6-oxoestrone (1476-34-2)

Guidance literature:

With pyridine; chromium(VI) oxide; In acetone; at 0 ℃; for 0.5h;

Reference yield: 93.0%

androst-4-ene-3,6,17,19-tetraone → 6-oxoestrone (1476-34-2)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 2h;

DOI:10.1248/cpb.52.983

Reference yield: 76.0%

3-acetoxyestra-1,3,5(10)-triene-6,17-dione (7323-89-9) → 6-oxoestrone (1476-34-2)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 3h;

DOI:10.1002/anie.201700243

upstream raw materials:

6-ketoestradiol

6-Hydroxy-oestron

estra-4-ene-3,17-dione

androst-4-ene-3,6,17-trione

Downstream raw materials:

17α-ethynyl-3,17β-dihydroxyestra-1,3,5(10)-trien-6-one

(8R,9S,13S,14S,17R)-6,17-Diethynyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,6,17-triol

3-hydroxy-13-methyl-8,9,11,12,13,14,15,16-octahydro-7H-cyclopenta[a]phenanthrene-6,17-dione bis-(O-methyl-oxime)

6β-hydroxyestradiol

Refernces

• 1、 Allan, Gillian M.,Lawrence, Harshani R.,Cornet, Josephine,Bubert, Christian,Fischer, Delphine S.,Vicker, Nigel,Smith, Andrew,Tutill, Helena J.,Purohit, Atul,Day, Joanna M.,Mahon, Mary F.,Reed, Michael J.,Potter, Barry V. L.. "Modification of estrone at the 6, 16, and 17 positions: Novel potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1". . p. 1325 - 1345. Retrieved 2007/10/03.
• 2、 -. "COMPOUND". Page 168-169. . Retrieved 2010/02/08.