2-amino-α-<(2-methoxyphenyl)methyl>-1,6-dihydro-5-nitro-6-oxo-4-pyrimidineacetonitrile

Base Information

Chemical Name:2-amino-α-<(2-methoxyphenyl)methyl>-1,6-dihydro-5-nitro-6-oxo-4-pyrimidineacetonitrile
CAS No.:140676-88-6
Molecular Formula:C₁₄H₁₃N₅O₄
Molecular Weight:315.288
Hs Code.:

Synonyms:2-amino-α-<(2-methoxyphenyl)methyl>-1,6-dihydro-5-nitro-6-oxo-4-pyrimidineacetonitrile

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Chemical Property of 2-amino-α-<(2-methoxyphenyl)methyl>-1,6-dihydro-5-nitro-6-oxo-4-pyrimidineacetonitrile

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Technology Process of 2-amino-α-<(2-methoxyphenyl)methyl>-1,6-dihydro-5-nitro-6-oxo-4-pyrimidineacetonitrile

There total 4 articles about 2-amino-α-<(2-methoxyphenyl)methyl>-1,6-dihydro-5-nitro-6-oxo-4-pyrimidineacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.3%

: 140676-84-2
2-amino-α-cyano-1,6-dihydro-5-nitro-6-oxo-α-<(2-methoxyphenyl)methyl>-4-pyrimidineacetic acid methyl ester

: 140676-88-6
2-amino-α-<(2-methoxyphenyl)methyl>-1,6-dihydro-5-nitro-6-oxo-4-pyrimidineacetonitrile

Guidance literature:: With sodium hydroxide; for 3.75h; Ambient temperature;
DOI:10.1021/jm00087a015

Reference yield:

: 72955-39-6
methyl 2-cyano-3-(2-methoxyphenyl)acrylate

: 140676-88-6
2-amino-α-<(2-methoxyphenyl)methyl>-1,6-dihydro-5-nitro-6-oxo-4-pyrimidineacetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 62.3 percent / NaBH₄, 1N NaOH / methanol; H₂O / 17 h / Ambient temperature

2: 1.) t-BuOK / 1.) DMSO, RT, 40 min, 2.) DMSO, a) RT 80 min, b) 65 deg C, 19 h

3: 78.3 percent / 1N NaOH / 3.75 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; potassium tert-butylate; In methanol; water;
DOI:10.1021/jm00087a015

Reference yield:

: 135-02-4
ortho-anisaldehyde

: 140676-88-6
2-amino-α-<(2-methoxyphenyl)methyl>-1,6-dihydro-5-nitro-6-oxo-4-pyrimidineacetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 73.4 percent / piperidine / dioxane / 1.) 0 deg C, 2 h, 2.) RT, 18 h

2: 62.3 percent / NaBH₄, 1N NaOH / methanol; H₂O / 17 h / Ambient temperature

3: 1.) t-BuOK / 1.) DMSO, RT, 40 min, 2.) DMSO, a) RT 80 min, b) 65 deg C, 19 h

4: 78.3 percent / 1N NaOH / 3.75 h / Ambient temperature

With piperidine; sodium hydroxide; sodium tetrahydroborate; potassium tert-butylate; In 1,4-dioxane; methanol; water;
DOI:10.1021/jm00087a015