(4-NITRO-PHENYL)-ACETALDEHYDE

Base Information

• Chemical Name: (4-NITRO-PHENYL)-ACETALDEHYDE
• CAS No.: 1460-05-5
• Molecular Formula: C8H7 N O3
• Molecular Weight: 165.148
• Hs Code.: 2913000090
• Mol file: 1460-05-5.mol

Synonyms:Acetaldehyde,(p-nitrophenyl)- (7CI,8CI); (4-Nitrophenyl)acetaldehyde; 4-Nitrobenzylaldehyde; 4-Nitrophenylethanal; p-Nitrophenylacetaldehyde

Chemical Property of (4-NITRO-PHENYL)-ACETALDEHYDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 85-86 °C
• Refractive Index: 1.561
• Boiling Point: 315.393°C at 760 mmHg
• Flash Point: 159.329°C
• PSA: 62.89000
• Density: 1.257g/cm³
• LogP: 1.85940
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

2-(4-nitrophenyl)acetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-NITRO-PHENYL)-ACETALDEHYDE

There total 35 articles about (4-NITRO-PHENYL)-ACETALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(4-nitrophenyl)ethanol (100-27-6) → p-nitrophenylacetaldehyde (1460-05-5)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In acetonitrile; at 80 ℃; for 2h;

DOI:10.1055/s-0030-1261032

Reference yield: 96.8%

1-(2-methoxyethenyl)-4-nitrobenzene (66821-15-6,66821-16-7,59436-14-5) → p-nitrophenylacetaldehyde (1460-05-5)

Guidance literature:

With hydrogenchloride; In water; acetonitrile; Reflux;

DOI:10.1016/j.bmcl.2010.04.144

Reference yield: 82.0%

4-nitrostyrene (100-13-0) → p-nitrophenylacetaldehyde (1460-05-5)

Guidance literature:

With ammonium persulfate; Pd(E-2-(benzylthio)-N-{(2-methoxynaphthalene-1-yl)methylene}benzenamine)Cl; 1-butyl-3-methylimidazolium Tetrafluoroborate; In water; at 70 ℃; for 0.25h; regioselective reaction; Microwave irradiation;

DOI:10.1016/j.jorganchem.2016.08.006

upstream raw materials:

(4-nitro-styryl)-carbamic acid methyl ester

1-dimethylamino-2-p-nitrophenyl-ethylene

1-<(4-Nitrophenyl)acetyl>imidazole

4-nitrostyrene

Downstream raw materials:

(4S,5R)-5-(4-Nitro-benzyl)-4,5-dihydro-oxazole-4-carboxylic acid ethyl ester

(2R,3S)-2-amino-3-hydroxy-4-(4-nitrophenyl)butanoic acid

(2R,5R)-1-Benzoyl-2-tert-butyl-5-[(S)-1-hydroxy-2-(4-nitro-phenyl)-ethyl]-3-methyl-imidazolidin-4-one

(2S,5S,1'R)-1-Benzoyl-5-<1'-hydroxy-2'-(4''-nitrophenyl)ethyl>-2-tert-butyl-3-methylimidazolidin-4-one

Refernces

• 1、 -. "Synthesis method of phenylacetaldehyde derivative". Paragraph 0041; 0046-0047; 0050. . Retrieved 2021/08/07.
• 2、 Grau, Benedikt W.,B?nisch, Simon,Neuhauser, Alexander,Hampel, Frank,G?rling, Andreas,Tsogoeva, Svetlana B.. "Facile Access to Challenging ortho-Terphenyls via Merging Two Multi-Step Domino Reactions in One-Pot: A Joint Experimental/Theoretical Study". . p. 3982 - 3992. Retrieved 2019/08/08.