methyl 3-(4-((3-(3-(methylsulfonyl)propoxy)phenyl)ethynyl)phenyl)propanoate

Base Information

Chemical Name:methyl 3-(4-((3-(3-(methylsulfonyl)propoxy)phenyl)ethynyl)phenyl)propanoate
CAS No.:1420837-20-2
Molecular Formula:C₂₂H₂₄O₅S
Molecular Weight:400.496
Hs Code.:

Synonyms:methyl 3-(4-((3-(3-(methylsulfonyl)propoxy)phenyl)ethynyl)phenyl)propanoate

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Chemical Property of methyl 3-(4-((3-(3-(methylsulfonyl)propoxy)phenyl)ethynyl)phenyl)propanoate

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Technology Process of methyl 3-(4-((3-(3-(methylsulfonyl)propoxy)phenyl)ethynyl)phenyl)propanoate

There total 4 articles about methyl 3-(4-((3-(3-(methylsulfonyl)propoxy)phenyl)ethynyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1420837-26-8
C₂₁H₂₁BrO₃

: 20277-69-4
sodium methansulfinate

: 1420837-20-2
methyl 3-(4-((3-(3-(methylsulfonyl)propoxy)phenyl)ethynyl)phenyl)propanoate

Guidance literature:: With PEG-400; at 45 ℃;
DOI:10.1021/jm301470a

Reference yield:

: 10401-11-3
3-hydroxy phenylacetylene

: 1420837-20-2
methyl 3-(4-((3-(3-(methylsulfonyl)propoxy)phenyl)ethynyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; sodium tetrachloropalladate(II) / water / 80 °C / Schlenk technique; Inert atmosphere

2: potassium carbonate / acetone / 20 °C / Reflux

3: PEG-400 / 45 °C

With copper(l) iodide; sodium tetrachloropalladate(II); N,N,N,N,-tetramethylethylenediamine; potassium carbonate; di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; In water; acetone; 1: |Sonogashira Cross-Coupling / 2: |Williamson Ether Synthesis;
DOI:10.1021/jm301470a

Reference yield:

: 75567-84-9
methyl 3-(4-bromopehynl)propanoate

: 1420837-20-2
methyl 3-(4-((3-(3-(methylsulfonyl)propoxy)phenyl)ethynyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; sodium tetrachloropalladate(II) / water / 80 °C / Schlenk technique; Inert atmosphere

2: potassium carbonate / acetone / 20 °C / Reflux

3: PEG-400 / 45 °C

With copper(l) iodide; sodium tetrachloropalladate(II); N,N,N,N,-tetramethylethylenediamine; potassium carbonate; di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; In water; acetone; 1: |Sonogashira Cross-Coupling / 2: |Williamson Ether Synthesis;
DOI:10.1021/jm301470a