(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(3-fluorophenyl)acrylamido)-4-methylpentanamide

Base Information

• Chemical Name: (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(3-fluorophenyl)acrylamido)-4-methylpentanamide
• CAS No.: 1392506-17-0
• Molecular Formula: C₃₄H₃₄ClFN₄O₃
• Molecular Weight: 601.12
• Mol file: 1392506-17-0.mol

Synonyms:(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(3-fluorophenyl)acrylamido)-4-methylpentanamide

Chemical Property of (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(3-fluorophenyl)acrylamido)-4-methylpentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(3-fluorophenyl)acrylamido)-4-methylpentanamide

There total 3 articles about (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(3-fluorophenyl)acrylamido)-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

3-Fluorocinnamic acid (20595-30-6) + (R)-2-amino-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-pentanamide (1392506-10-3) → (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(3-fluorophenyl)acrylamido)-4-methylpentanamide (1392506-17-0)

Guidance literature:

3-Fluorocinnamic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.333333h; Reflux;

(R)-2-amino-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-pentanamide; In dichloromethane; for 72h;

DOI:10.1016/j.ejmech.2012.05.022

Reference yield:

(R)-2-amino-N-(7-chloroquinolin-4-yl)-4-phenylbutanamide (1392506-08-9) → (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(3-fluorophenyl)acrylamido)-4-methylpentanamide (1392506-17-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

1.2: 24 h / 0 - 20 °C

2.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

2.2: pH 12

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / Reflux

3.2: 72 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.ejmech.2012.05.022

Reference yield:

(R)-tert-butyl (1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)carbamate (1392506-07-8) → (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(3-fluorophenyl)acrylamido)-4-methylpentanamide (1392506-17-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

1.2: pH 12

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

2.2: 24 h / 0 - 20 °C

3.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

3.2: pH 12

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / Reflux

4.2: 72 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.ejmech.2012.05.022

upstream raw materials:

(R)-tert-butyl (1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)carbamate

(R)-2-amino-N-(7-chloroquinolin-4-yl)-4-phenylbutanamide

3-Fluorocinnamic acid

(R)-2-amino-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-pentanamide