N-cyclohexyl-2-(4-(3-(5-fluoro-1H-indol-3-yl)-propyl)piperazin-1-yl)-N-(2-methoxyphenyl)acetamide

Base Information

Chemical Name:N-cyclohexyl-2-(4-(3-(5-fluoro-1H-indol-3-yl)-propyl)piperazin-1-yl)-N-(2-methoxyphenyl)acetamide
CAS No.:1452806-83-5
Molecular Formula:C₃₀H₃₉FN₄O₂
Molecular Weight:506.664
Hs Code.:

Synonyms:N-cyclohexyl-2-(4-(3-(5-fluoro-1H-indol-3-yl)-propyl)piperazin-1-yl)-N-(2-methoxyphenyl)acetamide

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Chemical Property of N-cyclohexyl-2-(4-(3-(5-fluoro-1H-indol-3-yl)-propyl)piperazin-1-yl)-N-(2-methoxyphenyl)acetamide

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Technology Process of N-cyclohexyl-2-(4-(3-(5-fluoro-1H-indol-3-yl)-propyl)piperazin-1-yl)-N-(2-methoxyphenyl)acetamide

There total 10 articles about N-cyclohexyl-2-(4-(3-(5-fluoro-1H-indol-3-yl)-propyl)piperazin-1-yl)-N-(2-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.8%

: N-cyclohexyl-N-(2-methoxyphenyl)-2-(piperazin-1-yl)acetamide trifluoroacetate

: 191013-68-0
3-(3-Bromopropyl)-5-fluoro-1H-indole

: 1452806-83-5
N-cyclohexyl-2-(4-(3-(5-fluoro-1H-indol-3-yl)-propyl)piperazin-1-yl)-N-(2-methoxyphenyl)acetamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 85 ℃; for 12h;
DOI:10.1021/acs.jcim.9b00926

Reference yield:

: 850570-34-2
N-(cyclohexylamino)-o-anisidine

: 1452806-83-5
N-cyclohexyl-2-(4-(3-(5-fluoro-1H-indol-3-yl)-propyl)piperazin-1-yl)-N-(2-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

2: potassium carbonate; potassium iodide / acetonitrile / 8 h / Reflux

3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

4: potassium carbonate / acetonitrile / 12 h / 80 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; In dichloromethane; acetonitrile;
DOI:10.1111/cbdd.12158

Reference yield:

: 141071-80-9
3-(5-fluoro-1H-indol-3-yl)propan-1-ol

: 1452806-83-5
N-cyclohexyl-2-(4-(3-(5-fluoro-1H-indol-3-yl)-propyl)piperazin-1-yl)-N-(2-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane

2: potassium carbonate / acetonitrile / 12 h / 80 °C

With carbon tetrabromide; potassium carbonate; triphenylphosphine; In dichloromethane; acetonitrile;
DOI:10.1111/cbdd.12158