1--1H-imidazole-4-acetic cid ethyl ester

Base Information

• Chemical Name: 1--1H-imidazole-4-acetic cid ethyl ester
• CAS No.: 128870-18-8
• Molecular Formula: C₂₈H₂₈N₂O₄
• Molecular Weight: 456.541
• Mol file: 128870-18-8.mol

Synonyms:1--1H-imidazole-4-acetic cid ethyl ester

Chemical Property of 1--1H-imidazole-4-acetic cid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1--1H-imidazole-4-acetic cid ethyl ester

There total 2 articles about 1--1H-imidazole-4-acetic cid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + (1H-imidazol-4-yl)-acetic acid ethyl ester (28782-45-8) → 1--1H-imidazole-4-acetic cid ethyl ester (128870-18-8)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/jo00304a026

Reference yield:

imidazole-4-acetic acid hydrochloride (3251-69-2) → 1--1H-imidazole-4-acetic cid ethyl ester (128870-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / conc. H₂SO₄ / 12 h / Heating

2: 76 percent / Et₃N / CH₂Cl₂

With sulfuric acid; triethylamine; In dichloromethane;

DOI:10.1021/jo00304a026

Reference yield: 91.0%

1--1H-imidazole-4-acetic cid ethyl ester (128870-18-8) + ethylenediamine (107-15-3,85404-18-8) → N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide (128870-19-9)

Guidance literature:

for 48h; Ambient temperature;

DOI:10.1021/jo00304a026

upstream raw materials:

4,4'-dimethoxytrityl chloride

(1H-imidazol-4-yl)-acetic acid ethyl ester

imidazole-4-acetic acid hydrochloride

Downstream raw materials:

N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide

5'-O--5-<3-<<2-<<<1--1H-imidazol-4-yl>acetyl>amino>ethyl>amino>-3-oxopropyl>-2'-deoxyuridine