N-acetyl-2-(3,4-dimethoxyphenyl)-2-(N-methylpyrrolidin-2-yl)-propylamine

Base Information

Chemical Name:N-acetyl-2-(3,4-dimethoxyphenyl)-2-(N-methylpyrrolidin-2-yl)-propylamine
CAS No.:157834-88-3
Molecular Formula:C₁₈H₂₈N₂O₃
Molecular Weight:320.432
Hs Code.:

Synonyms:N-acetyl-2-(3,4-dimethoxyphenyl)-2-(N-methylpyrrolidin-2-yl)-propylamine

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Chemical Property of N-acetyl-2-(3,4-dimethoxyphenyl)-2-(N-methylpyrrolidin-2-yl)-propylamine

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Technology Process of N-acetyl-2-(3,4-dimethoxyphenyl)-2-(N-methylpyrrolidin-2-yl)-propylamine

There total 5 articles about N-acetyl-2-(3,4-dimethoxyphenyl)-2-(N-methylpyrrolidin-2-yl)-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 157834-87-2
N-acetyl-2-(3,4-dimethoxyphenyl)-2-(N-methylpyrrol-2-yl)-propylamine

: 157834-88-3
N-acetyl-2-(3,4-dimethoxyphenyl)-2-(N-methylpyrrolidin-2-yl)-propylamine

Guidance literature:: With hydrogen; Rh on carbon; In acetic acid; for 120h; under 18751.5 Torr;
DOI:10.1002/ardp.19943270704

Reference yield:

: 81879-29-0
2-(3,4-dimethoxyphenyl)-2-(N-methylpyrrol-2-yl)-1-nitroethane

: 157834-88-3
N-acetyl-2-(3,4-dimethoxyphenyl)-2-(N-methylpyrrolidin-2-yl)-propylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 40 percent / P3)2>3 / 1,2-dichloro-ethane / 0.33 h / Heating

2: 1.) 15percent n-BuLi / 1.) THF, hexane, Et₂O, -70 deg C - -30 deg C, 2.) THF, hexane, Et₂O, r.t., 20 h

3: 90 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 5 h / Heating

4: 85 percent / 2 h / 50 °C

5: 66 percent / H₂ / Rh/C / acetic acid / 120 h / 18751.5 Torr

With lithium aluminium tetrahydride; n-butyllithium; hydrogen; Hexamethylphosphorous triamide; Rh on carbon; In tetrahydrofuran; diethyl ether; acetic acid; 1,2-dichloro-ethane;
DOI:10.1002/ardp.19943270704

Reference yield:

: 157834-86-1
2-(3,4-dimethoxyphenyl)-2-(N-methylpyrrol-2-yl)-propylamine

: 157834-88-3
N-acetyl-2-(3,4-dimethoxyphenyl)-2-(N-methylpyrrolidin-2-yl)-propylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / 2 h / 50 °C

2: 66 percent / H₂ / Rh/C / acetic acid / 120 h / 18751.5 Torr

With hydrogen; Rh on carbon; In acetic acid;
DOI:10.1002/ardp.19943270704