(R)-1-(1-(trans-4-aminocyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)ethanol

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Chemical Name:(R)-1-(1-(trans-4-aminocyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)ethanol
CAS No.:1315498-14-6
Molecular Formula:C₂₂H₂₅N₅O₃S
Molecular Weight:439.538
Hs Code.:

Synonyms:(R)-1-(1-(trans-4-aminocyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)ethanol

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Chemical Property of (R)-1-(1-(trans-4-aminocyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)ethanol

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Technology Process of (R)-1-(1-(trans-4-aminocyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)ethanol

There total 5 articles about (R)-1-(1-(trans-4-aminocyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1315498-13-5
C₂₇H₃₃N₅O₅S

: 1315498-14-6
(R)-1-(1-(trans-4-aminocyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)ethanol

Guidance literature:: With trifluoroacetic acid; In water; at 23 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm4004895

Reference yield:

: 1245649-52-8
1-(benzenesulfonyl)-4-chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine

: 1315498-14-6
(R)-1-(1-(trans-4-aminocyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / Inert atmosphere; Reflux

2.1: iron; ammonium chloride / ethanol; water / 4 h / Inert atmosphere; Reflux

3.1: triethyloxonium tetrafluoroborate / tetrahydrofuran / 2 h / 23 °C / Inert atmosphere

3.2: 2 h / Inert atmosphere; Reflux

4.1: trifluoroacetic acid / water / 1 h / 23 °C / Inert atmosphere

With triethyloxonium tetrafluoroborate; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; water; isopropyl alcohol;
DOI:10.1021/jm4004895

Reference yield:

: 1315500-19-6
trans-tert-butyl 4-(5-amino-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino)cyclohexylcarbamate

: 1315498-14-6
(R)-1-(1-(trans-4-aminocyclohexyl)-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethyloxonium tetrafluoroborate / tetrahydrofuran / 2 h / 23 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / water / 1 h / 23 °C / Inert atmosphere

With triethyloxonium tetrafluoroborate; trifluoroacetic acid; In tetrahydrofuran; water;
DOI:10.1021/jm4004895