(Z)-dimethyl 2-<(4-acetyl-3-hydroxy-2-propylphenyl)-amino>butene-1,4-dioate

Base Information

• Chemical Name: (Z)-dimethyl 2-<(4-acetyl-3-hydroxy-2-propylphenyl)-amino>butene-1,4-dioate
• CAS No.: 98331-40-9
• Molecular Formula: C₁₇H₂₁NO₆
• Molecular Weight: 335.357
• Mol file: 98331-40-9.mol

Synonyms:(Z)-dimethyl 2-<(4-acetyl-3-hydroxy-2-propylphenyl)-amino>butene-1,4-dioate

Chemical Property of (Z)-dimethyl 2-<(4-acetyl-3-hydroxy-2-propylphenyl)-amino>butene-1,4-dioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-dimethyl 2-<(4-acetyl-3-hydroxy-2-propylphenyl)-amino>butene-1,4-dioate

There total 4 articles about (Z)-dimethyl 2-<(4-acetyl-3-hydroxy-2-propylphenyl)-amino>butene-1,4-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-acetyl-3-hydroxyphenyl)acetamide (40547-58-8) → (Z)-dimethyl 2-<(4-acetyl-3-hydroxy-2-propylphenyl)-amino>butene-1,4-dioate (98331-40-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 81 percent / potassium carbonate / dimethylformamide / 5 h

2: 70 percent / various solvent(s) / 4 h / Heating

3: 98 percent / H₂ / PtO₂ / acetic acid / 2206.5 Torr

4: 93 percent / aq. HCl / 100 °C / Heating

5: ethanol / 17 h / Heating

With hydrogenchloride; hydrogen; potassium carbonate; platinum(IV) oxide; In ethanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00150a014

Reference yield:

4-Acetamido-2-allyloxyacetophenone (7298-72-8) → (Z)-dimethyl 2-<(4-acetyl-3-hydroxy-2-propylphenyl)-amino>butene-1,4-dioate (98331-40-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / various solvent(s) / 4 h / Heating

2: 98 percent / H₂ / PtO₂ / acetic acid / 2206.5 Torr

3: 93 percent / aq. HCl / 100 °C / Heating

4: ethanol / 17 h / Heating

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; acetic acid;

DOI:10.1021/jm00150a014

Reference yield:

1-(4-Acetylamino-3-(prop-2-enyl)-2-hydroxyphenyl)ethanone (69069-03-0) → (Z)-dimethyl 2-<(4-acetyl-3-hydroxy-2-propylphenyl)-amino>butene-1,4-dioate (98331-40-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / H₂ / PtO₂ / acetic acid / 2206.5 Torr

2: 93 percent / aq. HCl / 100 °C / Heating

3: ethanol / 17 h / Heating

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; acetic acid;

DOI:10.1021/jm00150a014

upstream raw materials:

N-(4-acetyl-3-hydroxyphenyl)acetamide

4-Acetamido-2-allyloxyacetophenone

1-(4-Acetylamino-3-(prop-2-enyl)-2-hydroxyphenyl)ethanone

1-(4-Acetylamino-2-hydroxy-3-propylphenyl)ethanone

Downstream raw materials:

dissodium 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quinoline-2,8-dicarboxylate

diethyl 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quilnoline-2,8-dicarboxylate

methyl 6-acetyl-7-hydroxy-4-phenoxy-8-propylquinoline-2-carboxylate

methyl 6-acetyl-4-chloro-7-hydroxy-8-propylquinoline-2-carboxylate