3-methoxy-4-((2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide

Base Information

Chemical Name:3-methoxy-4-((2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide
CAS No.:1400285-73-5
Molecular Formula:C₂₅H₂₉N₇O₂
Molecular Weight:459.551
Hs Code.:

Synonyms:3-methoxy-4-((2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide

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Chemical Property of 3-methoxy-4-((2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide

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Technology Process of 3-methoxy-4-((2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide

There total 11 articles about 3-methoxy-4-((2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1400284-64-1
tert-butyl 6-(2-methoxy-4-(1-methylpiperidin-4-ylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

: 1400285-73-5
3-methoxy-4-((2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide

Guidance literature:: tert-butyl 6-(2-methoxy-4-(1-methylpiperidin-4-ylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate; With trifluoroacetic acid; at 20 ℃; for 0.5h;

With ammonia; In methanol; dichloromethane; water;

Reference yield:

: 39806-89-8
4-ethynyl-1-methyl-1-H-pyrazole

: 1400285-73-5
3-methoxy-4-((2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.75 h / 60 °C / Inert atmosphere; Sealed vial

2: sodium hydroxide / methanol / 6 h / 25 °C

3: triethylamine / dmap / ethyl acetate / 0.42 h

4: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 3 h / 80 °C

5: trifluoroacetic acid / 0.5 h / 20 °C

With caesium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; dmap; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; ISOPROPYLAMIDE; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1201657-09-1
1-methyl-4-((trimethylsilyl)ethynyl)-1H-pyrazole

: 1400285-73-5
3-methoxy-4-((2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate; methanol / 2 h / 20 °C

2: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.75 h / 60 °C / Inert atmosphere; Sealed vial

3: sodium hydroxide / methanol / 6 h / 25 °C

4: triethylamine / dmap / ethyl acetate / 0.42 h

5: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 3 h / 80 °C

6: trifluoroacetic acid / 0.5 h / 20 °C

With methanol; potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; dmap; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; ISOPROPYLAMIDE; ethyl acetate; N,N-dimethyl-formamide;