Technology Process of 2-iodo-1,3,4-trimethoxy-5-methylbenzene
There total 2 articles about 2-iodo-1,3,4-trimethoxy-5-methylbenzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,2,5-trimethoxy-3-methylbenzene;
With
n-butyllithium;
In
diethyl ether; hexane;
at 0 - 20 ℃;
for 16h;
Inert atmosphere;
With
iodine;
In
diethyl ether; hexane;
at 0 - 20 ℃;
for 1h;
regioselective reaction;
Inert atmosphere;
DOI:10.1055/s-0033-1339281
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / Inert atmosphere; Reflux
1.2: Inert atmosphere
1.3: Inert atmosphere
2.1: n-butyllithium / diethyl ether; hexane / 16 h / 0 - 20 °C / Inert atmosphere
2.2: 1 h / 0 - 20 °C / Inert atmosphere
With
n-butyllithium; 3-chloro-benzenecarboperoxoic acid;
In
diethyl ether; hexane; chloroform;
DOI:10.1055/s-0033-1339281
- Guidance literature:
-
Multi-step reaction with 9 steps
1: copper / 3 h / 220 - 240 °C / Inert atmosphere
2: titanium tetrachloride / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere
3: 2,3-Dimethyl-2-butene; sodium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / dichloromethane; acetonitrile; water / 3 h / Inert atmosphere
4: methanol; hexane; toluene / 1 h / 0 °C / Inert atmosphere
5: boron trichloride / hexane; dichloromethane / -78 °C / Inert atmosphere
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 4.17 h / 0 - 20 °C
7: N-Bromosuccinimide; dibenzoyl peroxide; sodium acetate / tetrachloromethane / 1 h / Reflux; Inert atmosphere
8: potassium carbonate / methanol / 16 h / Inert atmosphere
9: 3-chloro-benzenecarboperoxoic acid; sodium acetate / dichloromethane / -78 - 0 °C / Inert atmosphere
With
sodium chlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; 2,3-Dimethyl-2-butene; dihydrogen peroxide; sodium acetate; boron trichloride; titanium tetrachloride; copper; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dibenzoyl peroxide;
In
methanol; tetrachloromethane; hexane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1055/s-0033-1339281
