1-(2-amino-phenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

Base Information

• Chemical Name: 1-(2-amino-phenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester
• CAS No.: 246851-80-9
• Molecular Formula: C₂₅H₂₆N₂O₄
• Molecular Weight: 418.492
• Mol file: 246851-80-9.mol

Synonyms:1-(2-amino-phenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

Chemical Property of 1-(2-amino-phenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-amino-phenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

There total 1 articles about 1-(2-amino-phenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + (S)-1-(2-aminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (246851-53-6) → 1-(2-amino-phenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester (246851-80-9)

Guidance literature:

DOI:10.1021/ja994437m

Reference yield:

1-(2-amino-phenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester (246851-80-9) → (S)-1-(2-Aziridin-1-yl-phenyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / diethyl ether / 0.75 h / 0 °C

2: 0.18 g / BH₃*THF / tetrahydrofuran / 14 h / 20 °C

3: 96 percent / H₂ / Pd/C / acetic acid

4: 39 percent / s-BuLi / tetrahydrofuran / 0.5 h / -78 °C

With pyridine; borane-THF; hydrogen; sec.-butyllithium; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; acetic acid;

DOI:10.1021/ja994437m

Reference yield:

1-(2-amino-phenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester (246851-80-9) → (2-Chloro-ethyl)-[2-((S)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-phenyl]-amine (271251-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / diethyl ether / 0.75 h / 0 °C

2: 0.18 g / BH₃*THF / tetrahydrofuran / 14 h / 20 °C

3: 96 percent / H₂ / Pd/C / acetic acid

With pyridine; borane-THF; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; acetic acid;

DOI:10.1021/ja994437m

upstream raw materials:

benzyl chloroformate

(S)-1-(2-aminophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Downstream raw materials:

tetramethylsulfamide

1-[2-(2-chloro-acetylamino)-phenyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

(2-Chloro-ethyl)-[2-((S)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-phenyl]-amine

1-[2-(2-chloro-ethylamino)-phenyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester