Z-LL-Nva-CHO

Base Information

Chemical Name:Z-LL-Nva-CHO
CAS No.:133407-86-0
Molecular Formula:C₂₅H₃₉N₃O₅
Molecular Weight:461.602
Hs Code.:
DSSTox Substance ID:DTXSID00432100
Nikkaji Number:J742.175C
Wikidata:Q27166869
ChEMBL ID:CHEMBL4518490
Mol file:133407-86-0.mol

Synonyms:benzyloxycarbonyl-leucyl-leucyl-norvalinal;carbobenzoxy-leucyl-leucyl-norvalinal;carbobenzoxyl-leucinyl-leucinyl-norvalinal-H;carbobenzyloxy-leucyl-leucyl-norvalinal;carbobenzyloxy-LLnV aldehyde;Cbz-Leu-Leu-norvalinal;MG 115;MG-115;MG115;N-carbobenzoxyl-L-leucinyl-L-leucinyl-L-norvalinal;Z-LLnV;ZLLnVal

Suppliers and Price of Z-LL-Nva-CHO

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Z-Leu-Leu-Nva-CHO
1mg
$ 265.00

TRC
MG-115
2.5mg
$ 90.00

Sigma-Aldrich
Z-Leu-Leu-Norvalinal ≥90% (HPLC), powder
5mg
$ 231.00

Sigma-Aldrich
MG-115 Potent reversible proteasome inhibitor (K
5mg
$ 195.17

Sigma-Aldrich
Z-Leu-Leu-Norvalinal ≥90% (HPLC), powder
1mg
$ 83.40

Cayman Chemical
(S)-MG115 ≥95%
5mg
$ 73.00

Cayman Chemical
(S)-MG115 ≥95%
1mg
$ 29.00

ApexBio Technology
MG-115
100mg
$ 700.00

ApexBio Technology
MG-115
25mg
$ 200.00

Adipogen Life Sciences
Z-Leu-Leu-Nva-CHO[MG-115] ≥95%(HPLC)
1 mg
$ 20.00

Total 14 raw suppliers

Chemical Property of Z-LL-Nva-CHO

Chemical Property:

Appearance/Colour:white powder
Boiling Point:678.8±55.0 °C(Predicted)
PKA:11.14±0.46(Predicted)
PSA：113.60000
Density:1.082±0.06 g/cm3(Predicted)
LogP:4.51490
Storage Temp.:−20°C
Solubility.:DMSO: soluble
XLogP3:4.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:15
Exact Mass:461.28897135
Heavy Atom Count:33
Complexity:617

Purity/Quality:

99%, ^*data from raw suppliers

Z-Leu-Leu-Nva-CHO ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES:CCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
Description (S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.
Uses (S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.[Cayman Chemical] MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.

Technology Process of Z-LL-Nva-CHO

There total 1 articles about Z-LL-Nva-CHO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: