2-(4'-N-tert-butyloxycarbonyl-methylaminophenyl)-6-bromobenzothiazole

Base Information

Chemical Name:2-(4'-N-tert-butyloxycarbonyl-methylaminophenyl)-6-bromobenzothiazole
CAS No.:1226795-31-8
Molecular Formula:C₁₉H₁₉BrN₂O₂S
Molecular Weight:419.342
Hs Code.:

Synonyms:2-(4'-N-tert-butyloxycarbonyl-methylaminophenyl)-6-bromobenzothiazole

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Chemical Property of 2-(4'-N-tert-butyloxycarbonyl-methylaminophenyl)-6-bromobenzothiazole

Chemical Property:

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Technology Process of 2-(4'-N-tert-butyloxycarbonyl-methylaminophenyl)-6-bromobenzothiazole

There total 6 articles about 2-(4'-N-tert-butyloxycarbonyl-methylaminophenyl)-6-bromobenzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 566169-98-0
2-(4'-methylaminophenyl)-6-bromobenzothiazole

: 1226795-31-8
2-(4'-N-tert-butyloxycarbonyl-methylaminophenyl)-6-bromobenzothiazole

Guidance literature:: In tetrahydrofuran; at 0 ℃; Reflux;
DOI:10.1016/j.bmc.2011.03.029

Reference yield:

: di-tert-butyl-dicarbonate

: 2-(4'-N-aminophenyl)-6-bromobenzenethiol

: 566169-98-0
2-(4'-methylaminophenyl)-6-bromobenzothiazole

: 1226795-31-8
2-(4'-N-tert-butyloxycarbonyl-methylaminophenyl)-6-bromobenzothiazole

Guidance literature:: With formaldehyd; sodium; acetic acid; In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1226795-31-8
2-(4'-N-tert-butyloxycarbonyl-methylaminophenyl)-6-bromobenzothiazole

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 0.5 h / 180 °C

2: ethanol; tin(ll) chloride / 2 h / 90 °C / Inert atmosphere

3: methanol / 1.5 h / Reflux

4: sodium cyanoborohydride; acetic acid / methanol / 1.5 h / 20 °C / pH 6

5: tetrahydrofuran / 0 °C / Reflux

With ethanol; sodium cyanoborohydride; acetic acid; tin(ll) chloride; In tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2011.03.029