7-bromo-3-(4-methoxybenzyl)-3,7b-dihydro-1H-cyclopropa[c]quinolin-2(1aH)-one

Base Information

Chemical Name:7-bromo-3-(4-methoxybenzyl)-3,7b-dihydro-1H-cyclopropa[c]quinolin-2(1aH)-one
CAS No.:1404431-46-4
Molecular Formula:C₁₈H₁₆BrNO₂
Molecular Weight:358.235
Hs Code.:

Synonyms:7-bromo-3-(4-methoxybenzyl)-3,7b-dihydro-1H-cyclopropa[c]quinolin-2(1aH)-one

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Chemical Property of 7-bromo-3-(4-methoxybenzyl)-3,7b-dihydro-1H-cyclopropa[c]quinolin-2(1aH)-one

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Technology Process of 7-bromo-3-(4-methoxybenzyl)-3,7b-dihydro-1H-cyclopropa[c]quinolin-2(1aH)-one

There total 4 articles about 7-bromo-3-(4-methoxybenzyl)-3,7b-dihydro-1H-cyclopropa[c]quinolin-2(1aH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1404431-45-3
5-bromo-1-(4-methoxybenzyl)quinolin-2(1H)-one

: 1774-47-6
trimethylsulfoxonium iodide

: 1404431-46-4
7-bromo-3-(4-methoxybenzyl)-3,7b-dihydro-1H-cyclopropa[c]quinolin-2(1aH)-one

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 1h; Inert atmosphere;

5-bromo-1-(4-methoxybenzyl)quinolin-2(1H)-one; In dimethyl sulfoxide; at 20 - 90 ℃; for 50h;

Reference yield:

: 4964-71-0
5-bromoquinoline

: 1404431-46-4
7-bromo-3-(4-methoxybenzyl)-3,7b-dihydro-1H-cyclopropa[c]quinolin-2(1aH)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C

2.1: trifluoroacetic anhydride / N,N-dimethyl-formamide / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 50 h / 20 - 75 °C

4.1: sodium hydride / dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere

4.2: 50 h / 20 - 90 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 99465-09-5
5-bromoquinolin-2(1H)-one

: 1404431-46-4
7-bromo-3-(4-methoxybenzyl)-3,7b-dihydro-1H-cyclopropa[c]quinolin-2(1aH)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 50 h / 20 - 75 °C

2.1: sodium hydride / dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere

2.2: 50 h / 20 - 90 °C

With sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;