(4R)-4-[(2R,4S,6R)-6-(4-hexynyl)-4-hydroxy-2-methoxytetrahydro-2H-pyran-2-yl]-3-(4-methoxybenzyl)-1,3-oxazolidin-2-one

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Chemical Name:(4R)-4-[(2R,4S,6R)-6-(4-hexynyl)-4-hydroxy-2-methoxytetrahydro-2H-pyran-2-yl]-3-(4-methoxybenzyl)-1,3-oxazolidin-2-one
CAS No.:928112-79-2
Molecular Formula:C₂₃H₃₁NO₆
Molecular Weight:417.502
Hs Code.:

Synonyms:(4R)-4-[(2R,4S,6R)-6-(4-hexynyl)-4-hydroxy-2-methoxytetrahydro-2H-pyran-2-yl]-3-(4-methoxybenzyl)-1,3-oxazolidin-2-one

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Chemical Property of (4R)-4-[(2R,4S,6R)-6-(4-hexynyl)-4-hydroxy-2-methoxytetrahydro-2H-pyran-2-yl]-3-(4-methoxybenzyl)-1,3-oxazolidin-2-one

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Technology Process of (4R)-4-[(2R,4S,6R)-6-(4-hexynyl)-4-hydroxy-2-methoxytetrahydro-2H-pyran-2-yl]-3-(4-methoxybenzyl)-1,3-oxazolidin-2-one

There total 8 articles about (4R)-4-[(2R,4S,6R)-6-(4-hexynyl)-4-hydroxy-2-methoxytetrahydro-2H-pyran-2-yl]-3-(4-methoxybenzyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 928112-78-1
4-[5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-undec-9-ynoyl]-3-(4-methoxy-benzyl)-oxazolidin-2-one

: 928112-79-2
(4R)-4-[(2R,4S,6R)-6-(4-hexynyl)-4-hydroxy-2-methoxytetrahydro-2H-pyran-2-yl]-3-(4-methoxybenzyl)-1,3-oxazolidin-2-one

Guidance literature:: 4-[5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-undec-9-ynoyl]-3-(4-methoxy-benzyl)-oxazolidin-2-one; With hydrogenchloride; In tetrahydrofuran;

With camphor-10-sulfonic acid; In methanol;
DOI:10.1002/chem.200601136

Reference yield: 49.0%

: 928112-80-5
(4R)-4-[(2R,4R,6R)-6-(4-hexynyl)-4-hydroxy-2-methoxytetrahydro-2H-pyran-2-yl]-3-(4-methoxybenzyl)-1,3-oxazolidin-2-one

: 928112-79-2
(4R)-4-[(2R,4S,6R)-6-(4-hexynyl)-4-hydroxy-2-methoxytetrahydro-2H-pyran-2-yl]-3-(4-methoxybenzyl)-1,3-oxazolidin-2-one

Guidance literature:: (4R)-4-[(2R,4R,6R)-6-(4-hexynyl)-4-hydroxy-2-methoxytetrahydro-2H-pyran-2-yl]-3-(4-methoxybenzyl)-1,3-oxazolidin-2-one; With di-isopropyl azodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran;

With potassium carbonate; In methanol;
DOI:10.1002/chem.200601136

Reference yield:

: 908370-94-5
dec-1-en-8-yn-4-ol

: 928112-79-2
(4R)-4-[(2R,4S,6R)-6-(4-hexynyl)-4-hydroxy-2-methoxytetrahydro-2H-pyran-2-yl]-3-(4-methoxybenzyl)-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2.05 g / imidazole / dimethylformamide

2.1: Sudan Red 7B; ozone / methanol / -78 °C

2.2: 67 percent / PPh₃ / methanol

3.1: TiCl₄ / CH₂Cl₂ / 0.33 h / -78 °C

3.2: (iPr)2NEt / CH₂Cl₂ / 3 h / 0 °C

3.3: 28 percent / CH₂Cl₂ / 3 h / -78 °C

4.1: aq. HCl / tetrahydrofuran

4.2: 92 percent / camphorsulfonic acid / methanol

With 1H-imidazole; hydrogenchloride; N-ethyl-1-[{4-(phenylazo)-phenyl}-azo]-2-naphthalenylamine; titanium tetrachloride; ozone; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.200601136