4-(1-hydroxy-2-methylpropan-2-yl)-N-(2-methyl-7-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzamide

Base Information

Chemical Name:4-(1-hydroxy-2-methylpropan-2-yl)-N-(2-methyl-7-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzamide
CAS No.:1189852-68-3
Molecular Formula:C₂₄H₂₄N₄O₂
Molecular Weight:400.48
Hs Code.:

Synonyms:4-(1-hydroxy-2-methylpropan-2-yl)-N-(2-methyl-7-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzamide

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Chemical Property of 4-(1-hydroxy-2-methylpropan-2-yl)-N-(2-methyl-7-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzamide

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Technology Process of 4-(1-hydroxy-2-methylpropan-2-yl)-N-(2-methyl-7-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzamide

There total 7 articles about 4-(1-hydroxy-2-methylpropan-2-yl)-N-(2-methyl-7-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1189852-21-8
N-(7-chloro-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide

: 98-80-6
phenylboronic acid

: 1189852-68-3
4-(1-hydroxy-2-methylpropan-2-yl)-N-(2-methyl-7-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzamide

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 110 ℃; Microwave irradiation;

Reference yield:

: 5798-75-4
Ethyl 4-bromobenzoate

: 1189852-68-3
4-(1-hydroxy-2-methylpropan-2-yl)-N-(2-methyl-7-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / tri-tert-butyl phosphine; palladium diacetate / 1,4-dioxane / 2 h / 110 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 - 20 °C

3.1: water; potassium hydroxide / tetrahydrofuran; methanol / 1 h / 70 °C

4.1: oxalyl dichloride / dichloromethane / 0.25 h

4.2: 2 h

5.1: 1-methyl-pyrrolidin-2-one / 14 h

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 60 h

6.2: pH 7 / Aqueous phosphate buffer

7.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 110 °C / Microwave irradiation

With 2,6-dimethylpyridine; oxalyl dichloride; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; caesium carbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tri-tert-butyl phosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water;

Reference yield:

: 1005785-98-7
ethyl 4-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)benzoate

: 1189852-68-3
4-(1-hydroxy-2-methylpropan-2-yl)-N-(2-methyl-7-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; potassium hydroxide / tetrahydrofuran; methanol / 1 h / 70 °C

2.1: oxalyl dichloride / dichloromethane / 0.25 h

2.2: 2 h

3.1: 1-methyl-pyrrolidin-2-one / 14 h

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 60 h

4.2: pH 7 / Aqueous phosphate buffer

5.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 110 °C / Microwave irradiation

With oxalyl dichloride; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water;