5B-Pregnane-3,6,20-trione

Base Information

• Chemical Name: 5B-Pregnane-3,6,20-trione
• CAS No.: 1239-92-5
• Molecular Formula: C₂₁H₃₀O₃
• Molecular Weight: 330.467
• Mol file: 1239-92-5.mol

Synonyms:5b-Pregnane-3,6,20-trione (8CI)

Chemical Property of 5B-Pregnane-3,6,20-trione

Chemical Property:

• PSA: 51.21000
• LogP: 3.98240

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5B-Pregnane-3,6,20-trione

There total 16 articles about 5B-Pregnane-3,6,20-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3α,6α-dihydroxy-5β-pregnan-20-one (570-78-5) → 5β-pregnane-3,6,20-trione (1239-92-5)

Guidance literature:

With chromium(VI) oxide; acetic acid; at 30 ℃;

DOI:10.1021/ja01213a052

Reference yield:

3α,6α-diacetoxy-5β-pregnanone-(20) (16826-57-6) → 6α-acetoxy-5β-pregnane-3,20-dione (96811-49-3) + 5β-pregnane-3,6,20-trione (1239-92-5)

Guidance literature:

With potassium hydroxide; und Behandeln des Reaktionsprodukts mit CrO₃ in wasserhaltiger Essigsaeure;

DOI:10.1021/ja01858a019

Reference yield:

methyl hyodeoxycholate (2868-48-6) → 5β-pregnane-3,6,20-trione (1239-92-5)

Guidance literature:

Multi-step reaction with 7 steps

1: toluene / Kochen der vom Aether befreiten Reaktionsloesung

2: glacial acetic acid; acetic acid anhydride / Erhitzen des Reaktionsprodukts mit wss.-methanol. NaOH

3: glacial acetic acid

4: tetrachloromethane; N-bromo-succinimide / Irradiation_.Behandeln des Reaktionsprodukts mit siedendem N,N-Dimethyl-anilin und Kochen des Reaktionsprodukts mit Acetanhydrid und Eisessig

5: acetic acid; chloroform; CrO₃ and aqueous acetic acid / 0 °C

6: methanol.KOH

7: CrO₃; water containing acetic acid / 30 °C

With chromium(VI) oxide; tetrachloromethane; potassium hydroxide; N-Bromosuccinimide; chloroform; acetic anhydride; acetic acid; toluene;

DOI:10.1021/ja01213a052

upstream raw materials:

3α,6α-dihydroxy-5β-pregnan-20-one

3α,6α-diacetoxy-5β-pregnanone-(20)

(3R,5R,6S,8S,9S,10R,13S,14S,17S)-17-((R)-1-Hydroxy-ethyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,6-diol

methyl hyodeoxycholate

Refernces

• 1、 Obermann,Spiteller-Friedmann,Spiteller. "Localisation of functional groups in steroids with the aid of mass spectrometry, I Keto steroids". . p. 1497 - 1511. Retrieved 2007/10/13.