(2S,3S)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester

Base Information

• Chemical Name: (2S,3S)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester
• CAS No.: 1374666-80-4
• Molecular Formula: C₉H₁₅NO₄
• Molecular Weight: 201.222
• Mol file: 1374666-80-4.mol

Synonyms:(2S,3S)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester

Chemical Property of (2S,3S)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester

There total 2 articles about (2S,3S)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-tert-butoxycarbonyl-L-allo-threonine (2592-18-9,23082-29-3,55674-67-4,85979-33-5,86748-77-8,23082-30-6) → (2S,3S)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester (1374666-80-4,710354-67-9)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1039/C8OB01756E

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (2S,3S)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester (1374666-80-4,710354-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / methanol; water / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In methanol; dichloromethane; water;

DOI:10.1021/jm300349j

Reference yield: 93.0%

(2S,3S)-allo-2-methyl-4-oxo-3-oxetanylcarbamic acid tert-butyl ester (1374666-80-4,710354-67-9) + Benzeneselenol (645-96-5) → (2R,3R)-2-tert-butoxycarbonylamino-3-phenylselanylbutanoicacid

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 3h;

DOI:10.1039/C8OB01756E

upstream raw materials:

di-tert-butyl dicarbonate

N-tert-butoxycarbonyl-L-allo-threonine