2,2-Dimethyl-propionic acid 2-{(2S,6R)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid 2-{(2S,6R)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester
CAS No.:224578-19-2
Molecular Formula:C₂₅H₃₃NO₆
Molecular Weight:443.54
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid 2-{(2S,6R)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester

Suppliers and Price of 2,2-Dimethyl-propionic acid 2-{(2S,6R)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2-Dimethyl-propionic acid 2-{(2S,6R)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid 2-{(2S,6R)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester

There total 11 articles about 2,2-Dimethyl-propionic acid 2-{(2S,6R)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027565-70-3
2,2-Dimethyl-propionic acid (3R,7R)-7-hydroxy-3-methanesulfonyloxy-7-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-5-methylene-heptyl ester

: 224578-19-2
2,2-Dimethyl-propionic acid 2-{(2S,6R)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester

Guidance literature:: With sodium hydride; In toluene; Yield given;
DOI:10.1016/S0040-4039(99)00209-9

Reference yield:

: 88920-24-5
p-methoxybenzyloxy acetic acid

: 224578-19-2
2,2-Dimethyl-propionic acid 2-{(2S,6R)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

2: DAST

3: 81 percent / BrCCl₃, DBU

4: 90 percent / DIBAL / CH₂Cl₂ / 0.17 h / -78 °C

5: 1.) (R,R)-1,2-diamino-1,2-diphenylethane bis-sulfonamide, BBr₃ / 1.) CH₂Cl₂, 12 h, 2.) CH₂Cl₂, -78 deg C

6: PPTs / CH₂Cl₂

7: TBAF / tetrahydrofuran

8: Et₃N / CH₂Cl₂

9: TsOH / methanol

10: NaH / toluene

With Bromotrichloromethane; (R,R)-1,2-diamino-1,2-diphenylethane bis-sulfonamide; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; boron tribromide; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4039(99)00209-9

Reference yield:

: 224578-16-9
2-(4-Methoxy-benzyloxymethyl)-oxazole-4-carbaldehyde

: 224578-19-2
2,2-Dimethyl-propionic acid 2-{(2S,6R)-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) (R,R)-1,2-diamino-1,2-diphenylethane bis-sulfonamide, BBr₃ / 1.) CH₂Cl₂, 12 h, 2.) CH₂Cl₂, -78 deg C

2: PPTs / CH₂Cl₂

3: TBAF / tetrahydrofuran

4: Et₃N / CH₂Cl₂

5: TsOH / methanol

6: NaH / toluene

With (R,R)-1,2-diamino-1,2-diphenylethane bis-sulfonamide; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; boron tribromide; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4039(99)00209-9