Benzothiazole, 2-(3-methylphenyl)- (9CI)

Base Information

• Chemical Name: Benzothiazole, 2-(3-methylphenyl)- (9CI)
• CAS No.: 1211-32-1
• Molecular Formula: C14H11 N S
• Molecular Weight: 225.314
• Hs Code.: 2934999090
• Mol file: 1211-32-1.mol

Synonyms:Benzothiazole,2-m-tolyl- (6CI,7CI,8CI)

Chemical Property of Benzothiazole, 2-(3-methylphenyl)- (9CI)

Chemical Property:

• PSA: 41.13000
• LogP: 4.27170

Purity/Quality:

99% ^*data from raw suppliers

2-(3-Methylphenyl)-1,3-benzothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzothiazole, 2-(3-methylphenyl)- (9CI)

There total 48 articles about Benzothiazole, 2-(3-methylphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,3-Benzothiazole (95-16-9) + 3-Iodotoluene (625-95-6) → 2-(m-tolyl)benzo[d]thiazole (1211-32-1)

Guidance literature:

With copper(l) iodide; 2-(N-butyl-benzimidazol-2-yl)-6-(diphenylphosphinoxy)phenylchloropalladium(II); caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.poly.2017.10.005

Reference yield: 98.0%

2-amino-benzenethiol (137-07-5) + m-tolyl aldehyde (620-23-5) → 2-(m-tolyl)benzo[d]thiazole (1211-32-1)

Guidance literature:

With tert.-butylhydroperoxide; iodine; potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 12h; Schlenk technique; Molecular sieve;

DOI:10.1039/c8ob02826e

Reference yield: 98.0%

1,3-Benzothiazole (95-16-9) + m-tolyl aldehyde (620-23-5) → 2-(m-tolyl)benzo[d]thiazole (1211-32-1)

Guidance literature:

With silver(I) 4-methylbenzenesulfonate; In water; at 100 ℃; for 12h; Sealed tube; Inert atmosphere; Green chemistry;

DOI:10.3987/COM-18-13934

upstream raw materials:

2-amino-benzenethiol

3-Methylbenzoyl chloride

2-[(2-Amino-phenylsulfanyl)-m-tolyl-methyl]-malonic acid diethyl ester

diethyl m-methylbenzylidenemalonate

Downstream raw materials:

2-<3-(bromomethyl)phenyl>-1,3-benzothiazole

(2-(benzo[d]thiazol-2-yl)-4-methylphenyl)(phenyl)methanone

2-?(2-?benzothiazolyl)?-?4-?methylphenol

2-(2,5-dimethylphenyl)benzo[d]thiazole

Refernces

• 1、 Imoto, Mitsutaka,Mizuno, Takumi,Nomoto, Akihiro,Ogawa, Akiya,Takeda, Motonori,Teramoto, Masahiro. "Synthesis of 2-Arylbenzothiazoles from Nitrobenzenes, Benzylamines, and Elemental Sulfur via Redox Cyclization". supporting information. p. 386 - 390. Retrieved 2022/03/02.
• 2、 Bai, Jin,Yan, Sijia,Zhang, Zhuxia,Guo, Zhen,Zhou, Cong-Ying. "Visible-Light Carbon Nitride-Catalyzed Aerobic Cyclization of Thiobenzanilides under Ambient Air Conditions". supporting information. p. 4843 - 4848. Retrieved 2021/06/28.