diethyl 2-(allylamino)-2-(4-(4-(trifluoromethyl)phenyl)but-3-ynyl)malonate

Base Information

Chemical Name:diethyl 2-(allylamino)-2-(4-(4-(trifluoromethyl)phenyl)but-3-ynyl)malonate
CAS No.:1374024-00-6
Molecular Formula:C₂₁H₂₄F₃NO₄
Molecular Weight:411.421
Hs Code.:

Synonyms:diethyl 2-(allylamino)-2-(4-(4-(trifluoromethyl)phenyl)but-3-ynyl)malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2-(allylamino)-2-(4-(4-(trifluoromethyl)phenyl)but-3-ynyl)malonate

Chemical Property:

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Technology Process of diethyl 2-(allylamino)-2-(4-(4-(trifluoromethyl)phenyl)but-3-ynyl)malonate

There total 5 articles about diethyl 2-(allylamino)-2-(4-(4-(trifluoromethyl)phenyl)but-3-ynyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₀F₃NO₄

: 106-95-6
allyl bromide

: 1374024-00-6
diethyl 2-(allylamino)-2-(4-(4-(trifluoromethyl)phenyl)but-3-ynyl)malonate

Guidance literature:: With lithium hydroxide monohydrate; In N,N-dimethyl-formamide; at 40 ℃; for 12h; Inert atmosphere;
DOI:10.1002/adsc.201100922

Reference yield:

: C₁₂H₈F₆O₃S

: 1374024-00-6
diethyl 2-(allylamino)-2-(4-(4-(trifluoromethyl)phenyl)but-3-ynyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

1.2: 12.5 h / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate / N,N-dimethyl-formamide / 12 h / 40 °C / Inert atmosphere

With lithium hydroxide monohydrate; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/adsc.201100922

Reference yield:

: C₂₃H₂₈F₃NO₆

: 1374024-00-6
diethyl 2-(allylamino)-2-(4-(4-(trifluoromethyl)phenyl)but-3-ynyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / tetrahydrofuran; dichloromethane / 0 - 20 °C / Inert atmosphere

2: lithium hydroxide monohydrate / N,N-dimethyl-formamide / 12 h / 40 °C / Inert atmosphere

With lithium hydroxide monohydrate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201100922