(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylonitrile

Base Information

Chemical Name:(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylonitrile
CAS No.:1333152-00-3
Molecular Formula:C₁₅H₁₃F₃N₄O
Molecular Weight:322.29
Hs Code.:

Synonyms:(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylonitrile

Chemical Property:

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Technology Process of (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylonitrile

There total 10 articles about (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333153-58-4
C₁₅H₁₅F₃N₄O₂

: 1333152-00-3
(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylonitrile

Guidance literature:: With phosphorus pentachloride; In 1,2-dichloro-ethane; Reflux; Inert atmosphere;

Reference yield:

: 149793-69-1
3-fluoro-5-trifluoromethyl-benzonitrile

: 1333152-00-3
(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

1.2: 14 h / 0 - 60 °C

2.1: thionyl chloride / toluene / 90 °C

3.1: magnesium(II) chloride hexahydrate; sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 20 °C

4.1: diethyl ether / 20 °C

5.1: N,N-dimethyl-formamide / 2 h / Reflux

6.1: dichloromethane / 0.5 h / 15 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

8.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

9.1: ammonia / tetrahydrofuran / Inert atmosphere

10.1: phosphorus pentachloride / 1,2-dichloro-ethane / Reflux; Inert atmosphere

With 4-methyl-morpholine; thionyl chloride; sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; phosphorus pentachloride; ammonia; water; sodium hydride; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1333153-40-4
3-isopropoxy-5-(trifluoromethyl)benzothioamide

: 1333152-00-3
(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: diethyl ether / 20 °C

2: N,N-dimethyl-formamide / 2 h / Reflux

3: dichloromethane / 0.5 h / 15 °C

4: water; lithium hydroxide / tetrahydrofuran / 20 °C

5: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

6: ammonia / tetrahydrofuran / Inert atmosphere

7: phosphorus pentachloride / 1,2-dichloro-ethane / Reflux; Inert atmosphere

With 4-methyl-morpholine; phosphorus pentachloride; ammonia; water; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;