1,1-Dimethylethyl 4-({5'-[({[3-(chloromethyl)phenyl]carbonyl}amino) methyl]-2'-fluoro-3-biphenylyl}methyl)-1-piperazinecarboxylate

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Chemical Name:1,1-Dimethylethyl 4-({5'-[({[3-(chloromethyl)phenyl]carbonyl}amino) methyl]-2'-fluoro-3-biphenylyl}methyl)-1-piperazinecarboxylate
CAS No.:1177558-88-1
Molecular Formula:C₃₁H₃₅ClFN₃O₃
Molecular Weight:552.089
Hs Code.:

Synonyms:1,1-Dimethylethyl 4-({5'-[({[3-(chloromethyl)phenyl]carbonyl}amino) methyl]-2'-fluoro-3-biphenylyl}methyl)-1-piperazinecarboxylate

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Chemical Property of 1,1-Dimethylethyl 4-({5'-[({[3-(chloromethyl)phenyl]carbonyl}amino) methyl]-2'-fluoro-3-biphenylyl}methyl)-1-piperazinecarboxylate

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Technology Process of 1,1-Dimethylethyl 4-({5'-[({[3-(chloromethyl)phenyl]carbonyl}amino) methyl]-2'-fluoro-3-biphenylyl}methyl)-1-piperazinecarboxylate

There total 1 articles about 1,1-Dimethylethyl 4-({5'-[({[3-(chloromethyl)phenyl]carbonyl}amino) methyl]-2'-fluoro-3-biphenylyl}methyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1177558-87-0
1,1-dimethylethyl 4-{[5'-(aminomethyl)-2'-fluoro-3-biphenylyl]methyl}-1-piperazinecarboxylate

: 31719-77-4
3-chloromethylbenzoic acid

: 1177558-88-1
1,1-Dimethylethyl 4-({5'-[({[3-(chloromethyl)phenyl]carbonyl}amino) methyl]-2'-fluoro-3-biphenylyl}methyl)-1-piperazinecarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; at 20 ℃; for 0.833333h;

Reference yield: 49.0%

: 1177558-86-9
1,6-diethyl-5-[(methylamino)methyl]-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine

: 1177558-88-1
1,1-Dimethylethyl 4-({5'-[({[3-(chloromethyl)phenyl]carbonyl}amino) methyl]-2'-fluoro-3-biphenylyl}methyl)-1-piperazinecarboxylate

: 1177558-89-2
1,1-Dimethylethyl 4-{[5'-({[(3-{[{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}(methyl)amino]methyl}phenyl)carbonyl]amino}methyl)-2'-fluoro-3-biphenylyl]methyl}-1-piperazinecarboxylate

Guidance literature:: 1,6-diethyl-5-[(methylamino)methyl]-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine; 1,1-Dimethylethyl 4-({5'-[({[3-(chloromethyl)phenyl]carbonyl}amino) methyl]-2'-fluoro-3-biphenylyl}methyl)-1-piperazinecarboxylate; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

With sodium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 25h;

Reference yield: 15.0%

: 931405-72-0
5-(aminomethyl)-1,6-diethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine

: 1177558-88-1
1,1-Dimethylethyl 4-({5'-[({[3-(chloromethyl)phenyl]carbonyl}amino) methyl]-2'-fluoro-3-biphenylyl}methyl)-1-piperazinecarboxylate

: 1177560-20-1
3-[({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)methyl]-N-{[6-fluoro-3'-(1-piperazinylmethyl)-3-biphenylyl]methyl}benzamide

Guidance literature:: 5-(aminomethyl)-1,6-diethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine; 1,1-Dimethylethyl 4-({5'-[({[3-(chloromethyl)phenyl]carbonyl}amino) methyl]-2'-fluoro-3-biphenylyl}methyl)-1-piperazinecarboxylate; With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 4h;

With sodium iodide; In dichloromethane; water; for 66h;

With tetrabutylammomium bromide; In dichloromethane; water; at 20 - 60 ℃; for 4.5h; Microwave irradiation;