3-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-1,5-dimethylhydantoin

Base Information

• Chemical Name: 3-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-1,5-dimethylhydantoin
• CAS No.: 349104-32-1
• Molecular Formula: C₁₅H₁₉IN₂O₄
• Molecular Weight: 418.231
• Mol file: 349104-32-1.mol

Synonyms:3-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-1,5-dimethylhydantoin

Chemical Property of 3-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-1,5-dimethylhydantoin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-1,5-dimethylhydantoin

There total 2 articles about 3-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-1,5-dimethylhydantoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-[2-(3,4-dimethoxyphenyl)ethyl]-1,5-dimethylhydantoin (349104-28-5) → 3-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-1,5-dimethylhydantoin (349104-32-1)

Guidance literature:

With Iodine monochloride; In acetic acid; at 20 ℃; for 5h;

DOI:10.1002/1099-0690(200104)2001:7<1267::aid-ejoc1267>3.3.co;2-e

Reference yield:

3-[2-(3,4-Dimethoxy-phenyl)-ethyl]-1-methyl-imidazolidine-2,4-dione (349104-55-8) → 3-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-1,5-dimethylhydantoin (349104-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: s-BuLi; TMEDA / tetrahydrofuran / 0.33 h / -78 °C

1.2: 72 percent / tetrahydrofuran / -78 °C

2.1: 99 percent / ICl / acetic acid / 5 h / 20 °C

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; Iodine monochloride; In tetrahydrofuran; acetic acid;

DOI:10.1002/1099-0690(200104)2001:7<1267::aid-ejoc1267>3.3.co;2-e

upstream raw materials:

3-[2-(3,4-dimethoxyphenyl)ethyl]-1,5-dimethylhydantoin

3-[2-(3,4-Dimethoxy-phenyl)-ethyl]-1-methyl-imidazolidine-2,4-dione