[(5E,7E,10E)-(2S,13S,14R)-13-(1-Ethoxy-ethoxy)-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:[(5E,7E,10E)-(2S,13S,14R)-13-(1-Ethoxy-ethoxy)-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester
CAS No.:213195-40-5
Molecular Formula:C₄₇H₇₀N₂O₈Si
Molecular Weight:819.167
Hs Code.:

[(5E,7E,10E)-(2S,13S,14R)-13-(1-Ethoxy-ethoxy)-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

Synonyms:[(5E,7E,10E)-(2S,13S,14R)-13-(1-Ethoxy-ethoxy)-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of [(5E,7E,10E)-(2S,13S,14R)-13-(1-Ethoxy-ethoxy)-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of [(5E,7E,10E)-(2S,13S,14R)-13-(1-Ethoxy-ethoxy)-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

There total 18 articles about [(5E,7E,10E)-(2S,13S,14R)-13-(1-Ethoxy-ethoxy)-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 109-92-2,25104-37-4
ethyl vinyl ether

: 213194-72-0
[(5E,7E,10E)-(2S,13S,14R)-13-Hydroxy-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

: 213195-40-5
[(5E,7E,10E)-(2S,13S,14R)-13-(1-Ethoxy-ethoxy)-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With pyridinium p-toluenesulfonate;
DOI:10.7164/antibiotics.51.688

Reference yield:

: 13857-47-1
(E)-4-methylhept-3-en-6-yn-1-ol

: 213195-40-5
[(5E,7E,10E)-(2S,13S,14R)-13-(1-Ethoxy-ethoxy)-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 99 percent / dimethylformamide

2.1: 88 percent / I₂ / Cp₂ZrCl₂ / CH₂Cl₂

3.1: 99 percent / TBAF / tetrahydrofuran

4.1: tetrahydrofuran

4.2: 52 percent / NaOEt / Pd(PPh₃)4 / ethanol; benzene / Heating

5.1: Dess-Martin reagent / CH₂Cl₂

6.1: 58 percent / Buⁿ2BOTf; Et₃N / CH₂Cl₂

7.1: 85 percent / PPTS

With di-n-butylboryl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; iodine; pyridinium p-toluenesulfonate; Dess-Martin periodane; triethylamine; zirconocene dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Etherification / 2.1: Addition / 3.1: Hydrolysis / 4.1: Addition / 4.2: Addition / 5.1: Dess-Martin oxidation / 6.1: Evans aldol reaction / 7.1: Etherification;
DOI:10.7164/antibiotics.51.688

Reference yield:

: 13927-59-8
(E)-7-acetoxy-4-methylhept-4-en-1-yne

: 213195-40-5
[(5E,7E,10E)-(2S,13S,14R)-13-(1-Ethoxy-ethoxy)-2,8,10,14-tetramethyl-15-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-15-oxo-pentadeca-5,7,10-trienyl]-(4-methoxy-benzyl)-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 98 percent / KCN / ethanol

2.1: 99 percent / dimethylformamide

3.1: 88 percent / I₂ / Cp₂ZrCl₂ / CH₂Cl₂

4.1: 99 percent / TBAF / tetrahydrofuran

5.1: tetrahydrofuran

5.2: 52 percent / NaOEt / Pd(PPh₃)4 / ethanol; benzene / Heating

6.1: Dess-Martin reagent / CH₂Cl₂

7.1: 58 percent / Buⁿ2BOTf; Et₃N / CH₂Cl₂

8.1: 85 percent / PPTS

With potassium cyanide; di-n-butylboryl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; iodine; pyridinium p-toluenesulfonate; Dess-Martin periodane; triethylamine; zirconocene dichloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Deacetylation / 2.1: Etherification / 3.1: Addition / 4.1: Hydrolysis / 5.1: Addition / 5.2: Addition / 6.1: Dess-Martin oxidation / 7.1: Evans aldol reaction / 8.1: Etherification;
DOI:10.7164/antibiotics.51.688