(2R,5S)-(4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetic acid benzyl ester

Base Information

Chemical Name:(2R,5S)-(4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetic acid benzyl ester
CAS No.:908298-92-0
Molecular Formula:C₂₆H₃₂N₂O₄
Molecular Weight:436.551
Hs Code.:

Synonyms:(2R,5S)-(4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetic acid benzyl ester

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Chemical Property of (2R,5S)-(4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetic acid benzyl ester

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Technology Process of (2R,5S)-(4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetic acid benzyl ester

There total 1 articles about (2R,5S)-(4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (5S)-4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazine

: 5437-45-6
Benzyl bromoacetate

: 908298-92-0
(2R,5S)-(4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetic acid benzyl ester

Guidance literature:: (5S)-4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

Benzyl bromoacetate; In tetrahydrofuran; at -78 ℃; for 3h;
DOI:10.1016/j.tetasy.2006.05.021

Reference yield: 100.0%

: 908298-92-0
(2R,5S)-(4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetic acid benzyl ester

: 1005192-50-6
C₁₉H₂₆N₂O₄

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 24h; under 3800.26 Torr;
DOI:10.1016/j.tetasy.2007.10.038

Reference yield:

: 908298-92-0
(2R,5S)-(4-benzyl-6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-acetic acid benzyl ester

: 908299-02-5
(2R,5S,2'S,5'R)-8'-(6-ethoxy-5-isopropyl-2-methyl-3-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl)-3',6'-diaza-4',7'-dioxo-2'-isopropyl-5'-methyl-5'-(benzyloxycarbonylmethyl)octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / liq. ammonia; Li / tetrahydrofuran; 2-methyl-propan-2-ol / -50 °C

2: 80 percent / triethylamine; HBTU / acetonitrile / 24 h / 20 °C

With ammonia; lithium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; acetonitrile; tert-butyl alcohol; 1: Birch reaction;
DOI:10.1016/j.tetasy.2006.05.021