(E)-1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-2-(3,4,5-trimethoxyphenyl)ethene

Base Information

Chemical Name:(E)-1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-2-(3,4,5-trimethoxyphenyl)ethene
CAS No.:134029-67-7
Molecular Formula:C₂₃H₃₂O₄Si
Molecular Weight:400.59
Hs Code.:

Synonyms:(E)-1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-2-(3,4,5-trimethoxyphenyl)ethene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-2-(3,4,5-trimethoxyphenyl)ethene

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of (E)-1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-2-(3,4,5-trimethoxyphenyl)ethene

There total 11 articles about (E)-1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-2-(3,4,5-trimethoxyphenyl)ethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 61240-20-8
triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide

: 134029-58-6
(Z)-1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-2-(3,4,5-trimethoxyphenyl)ethene

: 134029-67-7
(E)-1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-2-(3,4,5-trimethoxyphenyl)ethene

Guidance literature:: With sodium hydride; In benzene; for 16h; Ambient temperature;
DOI:10.1021/jm00112a036

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 108683-61-0
triphenyl(3,4,5-trimethoxybenzyl)phosphonium chloride

: 134029-67-7
(E)-1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-2-(3,4,5-trimethoxyphenyl)ethene

Guidance literature:: triphenyl(3,4,5-trimethoxybenzyl)phosphonium chloride; With n-butyllithium; In tetrahydrofuran; hexanes; at -20 ℃; for 0.333333h; Inert atmosphere;

p-[(tert-butyldimethylsilyl)oxy]benzaldehyde; In tetrahydrofuran; hexanes; at -20 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.03.049

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 134029-67-7
(E)-1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-2-(3,4,5-trimethoxyphenyl)ethene

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / LiAlH₄ / tetrahydrofuran / 3 h / 0 °C

2: 98 percent / tetrahydrofuran / 0.5 h / Heating

3: 88 percent / LiBr / tetrahydrofuran / 18 h / Heating

4: 81 percent / tetrahydrofuran / 22 h / Heating

5: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 3 h, 2.) THF, -78 deg C, 3 h

With lithium aluminium tetrahydride; sodium hexamethyldisilazane; lithium bromide; In tetrahydrofuran;
DOI:10.1021/jo00094a048