Technology Process of ethyl (13S)-9-cis-4-oxo-13,14-dihydroretinoate
There total 5 articles about ethyl (13S)-9-cis-4-oxo-13,14-dihydroretinoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
manganese(IV) oxide; sodium carbonate;
In
dichloromethane;
at 0 - 25 ℃;
for 5h;
Inert atmosphere;
DOI:10.1016/j.tet.2011.12.056
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 0.75 h / 130 °C / Inert atmosphere
2.2: 3 h / 0 - 25 °C / Inert atmosphere
3.1: manganese(IV) oxide; sodium carbonate / dichloromethane / 5 h / 0 - 25 °C / Inert atmosphere
With
N,N,N,N,N,N-hexamethylphosphoric triamide; manganese(IV) oxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; toluene;
1.1: Julia-Kocienski olefination / 2.2: Stille coupling;
DOI:10.1016/j.tet.2011.12.056
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 °C / Inert atmosphere
2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 0.75 h / 130 °C / Inert atmosphere
2.2: 3 h / 0 - 25 °C / Inert atmosphere
3.1: manganese(IV) oxide; sodium carbonate / dichloromethane / 5 h / 0 - 25 °C / Inert atmosphere
With
manganese(IV) oxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hexamethyldisilazane; sodium carbonate;
In
tetrahydrofuran; dichloromethane; toluene;
1.2: Horner-Wadsworth-Emmons olefination / 2.2: Stille coupling;
DOI:10.1016/j.tet.2011.12.056
