1,1,1-trifluoro-N-(2-phenyl-6,8-dihydro-5H-thiopyrano[3,4-d]pyrimidin-4-yl)methanesulfonamid

Base Information

Chemical Name:1,1,1-trifluoro-N-(2-phenyl-6,8-dihydro-5H-thiopyrano[3,4-d]pyrimidin-4-yl)methanesulfonamid
CAS No.:1436866-47-5
Molecular Formula:C₁₄H₁₁F₃N₂O₃S₂
Molecular Weight:376.38
Hs Code.:

Synonyms:1,1,1-trifluoro-N-(2-phenyl-6,8-dihydro-5H-thiopyrano[3,4-d]pyrimidin-4-yl)methanesulfonamid

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Chemical Property of 1,1,1-trifluoro-N-(2-phenyl-6,8-dihydro-5H-thiopyrano[3,4-d]pyrimidin-4-yl)methanesulfonamid

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Technology Process of 1,1,1-trifluoro-N-(2-phenyl-6,8-dihydro-5H-thiopyrano[3,4-d]pyrimidin-4-yl)methanesulfonamid

There total 1 articles about 1,1,1-trifluoro-N-(2-phenyl-6,8-dihydro-5H-thiopyrano[3,4-d]pyrimidin-4-yl)methanesulfonamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 38555-40-7
methyl 4-{[2-(methyloxy)-2-oxoethyl]thio}butanoate

: 1670-14-0
benzamidine monohydrochloride

: 1436866-46-4
1,1,1-trifluoro-N-(2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)methanesulfonamide

: 1436866-47-5
1,1,1-trifluoro-N-(2-phenyl-6,8-dihydro-5H-thiopyrano[3,4-d]pyrimidin-4-yl)methanesulfonamid

Guidance literature:: methyl 4-{[2-(methyloxy)-2-oxoethyl]thio}butanoate; With sodium methylate; In toluene; at 20 - 105 ℃; for 3h;

benzamidine monohydrochloride; With sodium methylate; In methanol; at 20 ℃; for 15h;

trifluoromethylsulfonic anhydride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2013.03.104

Reference yield: 78.0%

: 1436866-47-5
1,1,1-trifluoro-N-(2-phenyl-6,8-dihydro-5H-thiopyrano[3,4-d]pyrimidin-4-yl)methanesulfonamid

: 1436866-55-5
(7,7-dioxo-2-phenyl-6,8-dihydro-5H-thiopyrano[3,4-d]pyrimidin-4-yl) trifluoromethanesulfonate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2013.03.104

Reference yield:

: 1436866-47-5
1,1,1-trifluoro-N-(2-phenyl-6,8-dihydro-5H-thiopyrano[3,4-d]pyrimidin-4-yl)methanesulfonamid

: 1436866-56-6
2-[4-[(7,7-dioxo-2-phenyl-6,8-dihydro-5H-thiopyrano[3,4-d]pyrimidin-4-yl)amino]phenyl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

2: tetrahydrofuran / 23 h / 65 °C

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2013.03.104