(E)-5,5-bis[(phenylmethoxy)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-4,5-dihydrofuran-2-one

Base Information

Chemical Name:(E)-5,5-bis[(phenylmethoxy)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-4,5-dihydrofuran-2-one
CAS No.:862549-41-5
Molecular Formula:C₃₁H₄₂O₄
Molecular Weight:478.672
Hs Code.:

Synonyms:(E)-5,5-bis[(phenylmethoxy)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-4,5-dihydrofuran-2-one

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Chemical Property of (E)-5,5-bis[(phenylmethoxy)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-4,5-dihydrofuran-2-one

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Technology Process of (E)-5,5-bis[(phenylmethoxy)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-4,5-dihydrofuran-2-one

There total 9 articles about (E)-5,5-bis[(phenylmethoxy)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-4,5-dihydrofuran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 5,5-bis-benzyloxymethyl-3-(1-hydroxy-3-isobutyl-5-methyl-hexyl)-dihydro-furan-2-one

: 862549-41-5
(E)-5,5-bis[(phenylmethoxy)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-4,5-dihydrofuran-2-one

: 862549-43-7
(Z)-5,5-bis[(phenylmethoxy)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-4,5-dihydrofuran-2-one

Guidance literature:: 5,5-bis-benzyloxymethyl-3-(1-hydroxy-3-isobutyl-5-methyl-hexyl)-dihydro-furan-2-one; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1021/jm050352m

Reference yield:

: 108-83-8
diisobutyl ketone

: 862549-41-5
(E)-5,5-bis[(phenylmethoxy)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-4,5-dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 92 percent / tetrahydrofuran / -78 - 20 °C

2.1: 95 percent / PCC; molecular sieves 4 Angstroem / CH₂Cl₂ / 24 h / 20 °C

3.1: 64 percent / H₂ / Pd/C / CH₂Cl₂ / 3 h / 20 °C

4.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

4.2: 1.47 g / tetrahydrofuran / 1 h / -78 °C

5.1: triethylamine; methanesulfonyl chloride / CH₂Cl₂ / 0 - 20 °C

5.2: 31 percent / 1,8-diazabicyclo-[5.4.0]undec-7-ene / CH₂Cl₂ / 0.25 h / 20 °C

With 4 A molecular sieve; hydrogen; methanesulfonyl chloride; triethylamine; pyridinium chlorochromate; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050352m

Reference yield:

: 585538-79-0
5-methyl-3-(2-methylpropyl)hex-2-en-1-one

: 862549-41-5
(E)-5,5-bis[(phenylmethoxy)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-4,5-dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 64 percent / H₂ / Pd/C / CH₂Cl₂ / 3 h / 20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: 1.47 g / tetrahydrofuran / 1 h / -78 °C

3.1: triethylamine; methanesulfonyl chloride / CH₂Cl₂ / 0 - 20 °C

3.2: 31 percent / 1,8-diazabicyclo-[5.4.0]undec-7-ene / CH₂Cl₂ / 0.25 h / 20 °C

With hydrogen; methanesulfonyl chloride; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050352m