Technology Process of (2S,3S,6S)-2-Benzyloxymethyl-3-hydroxy-6-methoxycarbonylmethyl-piperidine-1-carboxylic acid methyl ester
There total 12 articles about (2S,3S,6S)-2-Benzyloxymethyl-3-hydroxy-6-methoxycarbonylmethyl-piperidine-1-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 88 percent / baker's yeast / H2O
2: 98 percent / Huenig base / CHCl3 / Heating
3: 96 percent / Super-Hydride / tetrahydrofuran / 0 °C
4: 95 percent / n-Bu3P, pyridine
5: 95 percent / Raney Ni (W-4) / ethanol
6: conc. HCl / methanol
7: 96 percent / NaH / dimethylformamide; benzene
8: 90 percent / Lawesson's reagent / tetrahydrofuran / Heating
9: 53 percent / PPh3, Et3N / acetonitrile / Heating
10: H2 / Pd(OH)2 / methanol
11: K2CO3
With
Lawessons reagent; pyridine; hydrogenchloride; baker's yeast; tributylphosphine; Raney Ni (W-4); hydrogen; sodium hydride; lithium triethylborohydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo990397t
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 98 percent / Huenig base / CHCl3 / Heating
2: 96 percent / Super-Hydride / tetrahydrofuran / 0 °C
3: 95 percent / n-Bu3P, pyridine
4: 95 percent / Raney Ni (W-4) / ethanol
5: conc. HCl / methanol
6: 96 percent / NaH / dimethylformamide; benzene
7: 90 percent / Lawesson's reagent / tetrahydrofuran / Heating
8: 53 percent / PPh3, Et3N / acetonitrile / Heating
9: H2 / Pd(OH)2 / methanol
10: K2CO3
With
Lawessons reagent; pyridine; hydrogenchloride; tributylphosphine; Raney Ni (W-4); hydrogen; sodium hydride; lithium triethylborohydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethanol; chloroform; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo990397t
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 95 percent / n-Bu3P, pyridine
2: 95 percent / Raney Ni (W-4) / ethanol
3: conc. HCl / methanol
4: 96 percent / NaH / dimethylformamide; benzene
5: 90 percent / Lawesson's reagent / tetrahydrofuran / Heating
6: 53 percent / PPh3, Et3N / acetonitrile / Heating
7: H2 / Pd(OH)2 / methanol
8: K2CO3
With
Lawessons reagent; pyridine; hydrogenchloride; tributylphosphine; Raney Ni (W-4); hydrogen; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo990397t
