N’-[(E)-(3,5-dibromo-2-hydroxyphenyl)methylene]isonicotinohydrazide

Base Information

• Chemical Name: N’-[(E)-(3,5-dibromo-2-hydroxyphenyl)methylene]isonicotinohydrazide
• CAS No.: 68639-25-8
• Molecular Formula: C₁₃H₉Br₂N₃O₂
• Molecular Weight: 399.041
• Mol file: 68639-25-8.mol

Synonyms:N’-[(E)-(3,5-dibromo-2-hydroxyphenyl)methylene]isonicotinohydrazide

Chemical Property of N’-[(E)-(3,5-dibromo-2-hydroxyphenyl)methylene]isonicotinohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N’-[(E)-(3,5-dibromo-2-hydroxyphenyl)methylene]isonicotinohydrazide

There total 2 articles about N’-[(E)-(3,5-dibromo-2-hydroxyphenyl)methylene]isonicotinohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

isoniazid (54-85-3,7640-37-1) + 3,5-Dibromosalicylaldehyde (90-59-5) → N'-(3,5-dibromo-2-hydroxybenzylidene)isonicotinohydrazide (68639-25-8)

Guidance literature:

In methanol; at 20 ℃; for 0.5h;

DOI:10.1134/S1070328414070082

Reference yield: 83.0%

isoniazid (54-85-3,7640-37-1) + 3,5-Dibromosalicylaldehyde (90-59-5) → N’-[(E)-(3,5-dibromo-2-hydroxyphenyl)methylene]isonicotinohydrazide (68639-25-8)

Guidance literature:

In methanol; for 4h; Heating;

Reference yield: 60.0%

DL-thiomalic acid (70-49-5,644-87-1) + N’-[(E)-(3,5-dibromo-2-hydroxyphenyl)methylene]isonicotinohydrazide (68639-25-8) → {2-(3,5-Dibromo-2-hydroxy-phenyl)-4-oxo-3-[(pyridine-4-carbonyl)-amino]-thiazolidin-5-yl}-acetic acid

Guidance literature:

With zinc(II) chloride; 160 deg C, 2 h and 180 deg C, 30 min;

upstream raw materials:

isoniazid

3,5-Dibromosalicylaldehyde