1-<2-bromo-1,1-(ethylenedioxy)ethyl>-carbamoyl-1-cyclobutane carboxamide

Base Information

Chemical Name:1-<2-bromo-1,1-(ethylenedioxy)ethyl>-carbamoyl-1-cyclobutane carboxamide
CAS No.:219322-95-9
Molecular Formula:C₁₇H₂₂BrNO₃
Molecular Weight:368.271
Hs Code.:

1-<2-bromo-1,1-(ethylenedioxy)ethyl>-<N-1(R)-phenylethyl>carbamoyl-1-cyclobutane carboxamide

Synonyms:1-<2-bromo-1,1-(ethylenedioxy)ethyl>-carbamoyl-1-cyclobutane carboxamide

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Chemical Property of 1-<2-bromo-1,1-(ethylenedioxy)ethyl>-carbamoyl-1-cyclobutane carboxamide

Chemical Property:

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Technology Process of 1-<2-bromo-1,1-(ethylenedioxy)ethyl>-carbamoyl-1-cyclobutane carboxamide

There total 8 articles about 1-<2-bromo-1,1-(ethylenedioxy)ethyl>-carbamoyl-1-cyclobutane carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 219322-94-8
1-<1,1-(ethylenedioxy)ethyl>-carbamoyl-1-cyclobutane carboxamide

: 219322-95-9
1-<2-bromo-1,1-(ethylenedioxy)ethyl>-carbamoyl-1-cyclobutane carboxamide

Guidance literature:: With bromine; In 1,4-dioxane; for 20h; Ambient temperature;
DOI:10.1248/cpb.46.1710

Reference yield:

: 3779-29-1
diethyl cyclobutane-1,1-dicarboxylate

: 219322-95-9
1-<2-bromo-1,1-(ethylenedioxy)ethyl>-carbamoyl-1-cyclobutane carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / 10 percent aq. KOH / methanol / 18 h / Ambient temperature

2: Et₃N / CHCl₃ / 0.33 h / Ambient temperature

3: CHCl₃ / 0.5 h / Ambient temperature

4: 94 percent / 20 percent aq. NaOH / ethanol / 1 h / Ambient temperature

5: thionyl chloride / benzene / 3 h / Heating

6: 1.) CuI / 1.) THF, Et₂O, -20 deg C, 20 min, 2.) THF, Et₂O, RT, 30 min

7: 16.5 g / p-toluenesulfonic acid monohydrate / benzene / 3 h / Heating

8: 99 percent / bromine / dioxane / 20 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; copper(l) iodide; thionyl chloride; bromine; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; methanol; ethanol; chloroform; benzene;
DOI:10.1248/cpb.46.1710

Reference yield:

: 54450-84-9
ethyl hydrogen cyclobutane-1,1-dicarboxylate

: 219322-95-9
1-<2-bromo-1,1-(ethylenedioxy)ethyl>-carbamoyl-1-cyclobutane carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CHCl₃ / 0.33 h / Ambient temperature

2: CHCl₃ / 0.5 h / Ambient temperature

3: 94 percent / 20 percent aq. NaOH / ethanol / 1 h / Ambient temperature

4: thionyl chloride / benzene / 3 h / Heating

5: 1.) CuI / 1.) THF, Et₂O, -20 deg C, 20 min, 2.) THF, Et₂O, RT, 30 min

6: 16.5 g / p-toluenesulfonic acid monohydrate / benzene / 3 h / Heating

7: 99 percent / bromine / dioxane / 20 h / Ambient temperature

With sodium hydroxide; copper(l) iodide; thionyl chloride; bromine; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; ethanol; chloroform; benzene;
DOI:10.1248/cpb.46.1710