1-[2-(2,3-Dihydro-1H-cyclopenta[b]naphthalen-6-yl)ethyl]-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine

Base Information

Chemical Name:1-[2-(2,3-Dihydro-1H-cyclopenta[b]naphthalen-6-yl)ethyl]-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine
CAS No.:514211-78-0
Molecular Formula:C₂₇H₂₈F₃NO
Molecular Weight:439.521
Hs Code.:

Synonyms:1-[2-(2,3-Dihydro-1H-cyclopenta[b]naphthalen-6-yl)ethyl]-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine

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Chemical Property of 1-[2-(2,3-Dihydro-1H-cyclopenta[b]naphthalen-6-yl)ethyl]-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine

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Technology Process of 1-[2-(2,3-Dihydro-1H-cyclopenta[b]naphthalen-6-yl)ethyl]-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine

There total 1 articles about 1-[2-(2,3-Dihydro-1H-cyclopenta[b]naphthalen-6-yl)ethyl]-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 514211-77-9
1-[4-Hydroxy-4-(3-trifluoromethylphenyl)-1-piperidinyl]-2-(2,3-dihydro-1H-cyclopenta[b]naphthalen-6-yl)-1-ethanone

: 514211-78-0
1-[2-(2,3-Dihydro-1H-cyclopenta[b]naphthalen-6-yl)ethyl]-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine

Guidance literature:: 1-[4-Hydroxy-4-(3-trifluoromethylphenyl)-1-piperidinyl]-2-(2,3-dihydro-1H-cyclopenta[b]naphthalen-6-yl)-1-ethanone; With borane dimethyl sulfide complex; In tetrahydrofuran; for 4h; Heating / reflux;

With methanol; In tetrahydrofuran; for 0.583333h; Heating / reflux;

Reference yield:

: 514211-78-0
1-[2-(2,3-Dihydro-1H-cyclopenta[b]naphthalen-6-yl)ethyl]-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine

: 1-[2-(2,3-dihydro-1H-cyclopenta[b]naphthalen-6-yl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride

Guidance literature:: 1-[2-(2,3-Dihydro-1H-cyclopenta[b]naphthalen-6-yl)ethyl]-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine; With sulfuric acid; In acetic acid; at 80 ℃; for 2h;

With ammonium hydroxide; In water; acetic acid;

With hydrogenchloride; In water; isopropyl alcohol;