(S)-2-(2-{[(2S,3S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid

Base Information

Chemical Name:(S)-2-(2-{[(2S,3S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid
CAS No.:210753-53-0
Molecular Formula:C₅₁H₆₄N₄O₅S₂
Molecular Weight:877.225
Hs Code.:

(S)-2-(2-{[(2S,3S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid

Synonyms:(S)-2-(2-{[(2S,3S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid

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Chemical Property of (S)-2-(2-{[(2S,3S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid

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Technology Process of (S)-2-(2-{[(2S,3S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid

There total 7 articles about (S)-2-(2-{[(2S,3S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 180311-62-0
(S)-2-(2-{[(2S,3S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid methyl ester

: 210753-53-0
(S)-2-(2-{[(2S,3S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid

Guidance literature:: With sodium hydroxide; In methanol; at 0 ℃; for 5h;
DOI:10.1021/jm9800907

Reference yield:

: 118171-79-2,141321-51-9,141321-54-2,87694-55-1
N-(t-butoxycarbonyl)-isoleucine aldehyde

: 210753-53-0
(S)-2-(2-{[(2S,3S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid

Guidance literature:: Multi-step reaction with 7 steps

1: 54 percent / Na(OAc)3BH, Et₃N, 3A molecular sieves / 1,2-dichloro-ethane; dimethylformamide / 18 h

2: 3.8 g / Na(OAc)3BH, 3A molecular sieves / 1,2-dichloro-ethane / 16 h / Ambient temperature

3: 2.29 g / 1 N aq. NaOH / methanol / 4 h / Ambient temperature

4: 2.82 g / HOBT, EDC, Et₃N / dimethylformamide / 24 h / Ambient temperature

5: 2.68 g / HCl (gas) / ethyl acetate / -25 °C

6: 53 percent / NaCNBH₃, KOAc, 3A molecular sieves / methanol / 18 h / Ambient temperature

7: 74 percent / 1 N aq. NaOH / methanol / 5 h / 0 °C

With hydrogenchloride; sodium hydroxide; 3 A molecular sieve; potassium acetate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907

Reference yield:

: 168539-97-7
N-(2(S)-(t-butoxycarbonylamino)-3(S)-methylpentyl)glycine methyl ester

: 210753-53-0
(S)-2-(2-{[(2S,3S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 3.8 g / Na(OAc)3BH, 3A molecular sieves / 1,2-dichloro-ethane / 16 h / Ambient temperature

2: 2.29 g / 1 N aq. NaOH / methanol / 4 h / Ambient temperature

3: 2.82 g / HOBT, EDC, Et₃N / dimethylformamide / 24 h / Ambient temperature

4: 2.68 g / HCl (gas) / ethyl acetate / -25 °C

5: 53 percent / NaCNBH₃, KOAc, 3A molecular sieves / methanol / 18 h / Ambient temperature

6: 74 percent / 1 N aq. NaOH / methanol / 5 h / 0 °C

With hydrogenchloride; sodium hydroxide; 3 A molecular sieve; potassium acetate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907